Applications and benefits of PAT


Click here to start

Table of Contents

Applications and benefits of PAT


No sampling No operator exposure Accurate end point Control of impurities

Focused Beam Reflectance Measurement

Crystal size change during formation

Endoscope picture inside crystalliser

Pan Dryer

PPT Slide

NIR on a fluid bed dryer - granule drying

Glatt Multi-Cell Fluid Bed Dryer

On-Line analysis of blending

On- line NIR bin blender

PPT Slide

Saccharin Specific Absorption

Magnesium Stearate Specific Absorption

Absorbance of Blend Components (Step 1)

Saccharin Uniformity (Step 1)

Magnesium Stearate Uniformity (Step 2)

NIR Instrument in production plant

Blender Filling

Online Monitoring of Aromatic Absorption

Online Monitoring of Aromatic Absorption

On-line blending - benefits

NIR Tablet Transmission Device

Tablet core potency - blend segregation in the bin

Automated tablet analysis

Bruker NIR Transmission Head

Absorbance of active tablets Vs placebos

NIR transmission Vs conc in tablets 0.1% - 2.0%

On-line tablet cores - benefits

Microscopic View of Dosage Form

The Future…..

Benefits of Improved Control

Author: Simon Maris