VRBPAC Teleconference March 6, 2002 Preliminary Summary

Session #1-Open Session

B Strain Selection for Influenza Virus Vaccine for the 2002-2003 Season

The panel heard presentations on strains of circulating influenza virus. After discussion, the committee made the following recommendations for the influenza virus strains to be included in vaccine for use during the 2002-2003 season in the United States.

The January 30, 2002 recommendation of the advisory committee regarding the vaccine strain A composition was to retain both the H1N1, A/New Caledonia/20/99, and the H3N2, A/Panama/2007/99, influenza strains used from the current 2001-2002 season.

Based on information about the appearance and epidemiology of new influenza virus variants, responses to current vaccines, and the availability of strains and reagents needed for manufacturing, the committee made the recommendation to change the B component of the current 2001-2002 vaccine to a new B strain formulation.

1) H1N1, A/New Caledonia/20/99,

2) H3N2, A/Panama/2007/99 (an A/Moscow/10/99-like virus),

3) B/Hong Kong/330/2001-like virus strain

1) There is currently not much evidence to support the safety and efficacy of using a 15 ug quadrivalent vaccine.

2) A large-scale clinical study is needed to evaluate the safety and efficacy of a quadrivalent vaccine.

3) A quadrivalent vaccine using 15 ug would reduce the total number of doses available for distribution in vaccine production.

4) Creating a quadrivalent vaccine would delay the 2002-2003 vaccine availability.