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Table of Contents


Sarcomas: Themes

Distribution of Common Pediatric Malignancies

The Sarcomas

Five Year Survival Rates Among Children with Sarcomas: Improvement Over Time

Osteosarcoma: Distribution by Site, Age, and Sex

Molecular Derangements in Osteosarcoma

Multi-Institutional Osteosarcoma Study (1981-1986): Outcome of All Patients Treated with Chemotherapy

Intergroup Osteosarcoma Study (1993-1997): Event-Free Survival for all Patients

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Ewing Sarcoma: Distribution by Site, Age and Sex

Molecular Pathogenetic Mechanisms in Rhabdomyosarcoma and Ewing’s Sarcoma

The 11;22 Translocation And The Family of Ewing’s Sarcomas

Effect of Presence of Metastases on EFS

EFS for All Non-Metastatic Patients by Location

EFS for Non-Metastatic Patients by Age



Common Histiotypes of Rhabdomyosarcoma

Survival by Histology

Gene Fusions with Novel Chimeric Protein Products

Genetic Features of Rhabdomyosarcoma

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Tumor Histologic Subgroup Distribution by Age Group

Disease Stage Distribution by Age Group

Results of Univariate Analysis

Estimated Relative Risk of Failure by Age Group (Cox Proportional Hazards Model)

The Common Soft Tissue Sarcomas in Children

Molecular Diagnosis of Sarcomas

Outcome of Children with Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas

Considerations of Linking Studies of Sarcomas

Challenges in Linking Studies in Children and Adults

Novel Targets for Biological Agents in Sarcomas

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Author: Michael Link, M.D.