69th Meeting - June 14-15, 2001

Briefing Information

June 15, 2001

IV. Transfusion-Related Acute Lung Injury - informational Presentation

Introduction and Background - Leslie Holness, MD, Medical Officer, Division of Blood Applications  pdf

Transfusion Related Acute Lung Injury (TRALI), Leslie Holness, MD, Medical Officer, Division of Blood Applications   pdf

Transfusion Related Acute Lung Injury - Mark Popovsky, M.D., Haemonetics Corp.   pdf

HLA Class II Antibodies in TRALI - Patricia Kopko, M.D., Sacramento Blood Center   pdf

V. Studies on Leukoreduction Filtration Failures

Introduction and Background - Betsy Poindexter, Biologist, Lab. of Cellular Hematology, DH B.    pdf   rtf

Pathophysiology of Sickle Cell Anemia: Hemoglobin S Polymerization - Constance Noguchi,Ph.D., NIH   pdf   ppt   html

Abstracts of Articles*

Noguchi CT,  Polymerization in erythrocytes containing S and non-S hemoglobins, Biophys J 1984 Jun;45(6):1153-8

Gupta AK, Kirchner KA, Nicholson R, Adams JG 3rd, Schechter AN, Noguchi CT, Steinberg MH, Effects of alpha-thalassemia and sickle polymerization tendency on the urine-concentrating defect of individuals with sickle cell trait, J Clin Invest 1991 Dec;88(6):1963-8

Hiruma H, Noguchi CT, Uyesaka N, Schechter AN, Rodgers GP, Contributions of sickle hemoglobin polymer and sickle cell membranes to impaired filterability, Am J Physiol 1995 May;268(5 Pt 2):H2003-8

Leukoreduction Experience in the American Red Cross - Rebecca Haley, MD, American Red Cross   pdf

Sickle Cell Disease, Jeanne A. Smith, MD, MPH   pdf   html

Abstract of Martin Ruta Presentation at the AABB 2000 meeting   pdf

Guidance for Industry: Pre-Storage Leukocyte Reduction of Whole Blood and Blood Components Intended for Transfusion, January 2001   pdf

*Articles contain copyrighted material.  These documents may be viewed at:  Dockets Management Branch, Food and Drug Administration, 5630 Fishers Lane, Room 1061, Rockville, MD  20852 between the hours of 9:00 am and 4:00 pm Monday through Friday, except for Federal holidays.