Preclinical Studies


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Preclinical Studies

Tegaserod Carcinogenicity Studies

Increased Incidence of Intestinal Tumors in Tegaserod Mouse Carcinogenicity Study

Mouse Small Intestinal Tumors

Body Weight Curves in the Tegaserod Mouse Carcinogenicity Study

Tegaserod Has No Mutagenic Potential

Tegaserod Induces Reversible Hyperplasia in Mouse Intestinal Mucosa

Tumors Result From Epigenetic Effects

Sustained Hyperplasia Is Required for Tumor Formation

The Tumor Incidence Was Only Increased at a Very High Tegaserod Dose

Tegaserod Therapy Poses No Carcinogenic Risk

Author: Sector Pharma