Saquinavir and virologic efficacy
Some (but not all) studies show, in retrospective, relationships between saquinavir pharmacokinetics and HIV-1 RNA response.
These relationships have been established in na´ve and NRTI-pretreated patients.
Reported pharmacokinetic parameters are AUC and Cmin (all correlated).
No clear data on such relationships when saquinavir is used in combination with (low dose) ritonavir.