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  1. Development Resources

Fluconazole Injection, Oral

Exceptions to the Recognized Standard

 

Minimum Inhibitory
Concentrations

(mcg/mL)
Broth Microdilution
at 24 Hours

Disk Diffusion
(zone diameters in mm)

Disk Diffusion at 24 Hours

Pathogena

S

Ic

R

S

Ic

R

Candida albicans

M27M44Sb

4

M27M44Sb

M27M44Sb

14-16

M27M44Sb

Candida glabrata

M27M44Sb

< 32

M27M44Sb

M27M44Sb

>15

M27M44Sb

Candida parapsilosis

M27M44Sb

4

M27M44Sb

M27M44Sb

14-16

M27M44Sb

Candida tropicalis

M27M44Sb

4

M27M44Sb

M27M44Sb

14-16

M27M44Sb

S = Susceptible; I = Intermediate; R = Resistant
a Isolates of C. krusei are assumed to be intrinsically resistant to fluconazole and their MICs and/or zone diameters should not be interpreted using this scale.
b M27M44S standard is recognized.
c The term “SDD” is not recognized pending further clarification of the definition of the term by standards development organizations. For isolates testing “I”, doses higher than 6 mg/kg/day should be considered.

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