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  1. Development & Approval Process (Drugs)

Fluconazole

Fluconazole

Exceptions to the Recognized Standard

 

Minimum Inhibitory
Concentrations

(mcg/mL)
Broth Microdilution
at 24 Hours

Disk Diffusion
(zone diameters in mm)

Disk Diffusion at 24 Hours

Pathogena

S

Ic

R

S

Ic

R

Candida albicans

M60b

4

M60b

M60b

14-16

M60b

Candida glabrata

M60b

< 32

M60b

M60b

>15

M60b

Candida parapsilosis

M60b

4

M60b

M60b

14-16

M60b

Candida tropicalis

M60b

4

M60b

M60b

14-16

M60b

S = Susceptible; I = Intermediate; R = Resistant
a Isolates of C. krusei are assumed to be intrinsically resistant to fluconazole and their MICs and/or zone diameters should not be interpreted using this scale.
b M60 standard is recognized.
c The term “SDD” is not recognized pending further clarification of the definition of the term by standards development organizations. For isolates testing “I”, doses higher than 6 mg/kg/day should be considered.