Tianeptine
Tianeptine is not approved by the U.S. Food and Drug Administration for any medical use. Despite that, some companies are illegally marketing and selling products containing tianeptine to consumers. They are also making dangerous and unproven claims that tianeptine can improve brain function and treat anxiety, depression, pain, opioid use disorder, and other conditions.
In the U.S., reports of severe side effects involving tianeptine are increasing. Poison control center cases involving tianeptine exposure have increased nationwide, from 11 total cases between 2000 and 2013 to 151 cases in 2020 alone.
- HCP Letter: New “Gas Station Heroin” Tianeptine Product Trend (5/8/2025)
- FDA warns consumers not to purchase or use Neptune’s Fix or any tianeptine product due to serious risks (2/15/2024)
- OCI Press Release - California Man Sentenced for Smuggling Fraudulent Cognitive Enhancement Drug Into the United States from China (2/15/2024)
- OCI Press Release - Arizona Company and CEO Sentenced for Illegal Distribution of Tianeptine and Other Drugs and Ordered to Forfeit $2.4 Million (2/5/2024)
- U.S. Food and Drug Administration Letter to Trade Associations (1/31/2024)
- Neptune Resources, LLC Issues Voluntary Nationwide Recall of Neptune’s Fix (1/28/2024)
- DOJ Press Release - California Man Pleads Guilty to Smuggling Alleged Cognitive Enhancement Drug into the United States from China (9/7/2023)
- Flickr - Tianeptine Product Images
- Consumer Update - Tianeptine Products Linked to Serious Harm, Overdoses, Death
- Tianeptine in Dietary Supplements
- DEA Diversion Control Division - Tianeptine
- CDC Morbidity and Mortality Weekly Report: Notes from the Field: Cluster of Severe Illness from Neptune’s Fix Tianeptine Linked to Synthetic Cannabinoids — New Jersey, June–November 2023