U.S. flag An official website of the United States government
  1. Home
  2. Animal & Veterinary
  3. Development & Approval Process
  4. Drugs Transitioning from Over-the-Counter (OTC) to Prescription (Rx) Status
  1. Animal & Veterinary

Drugs Transitioning from Over-the-Counter (OTC) to Prescription (Rx) Status

Drugs Transitioning from Over-the-Counter (OTC) to Prescription (Rx) Status

Printer-friendly PDF

This list represents the antimicrobials approved for use in water affected by GFI #213. The complete list of affected applications will continue to be updated as changes are made and can be located here.

Upon completion of their voluntary transition from OTC to Rx, all uses of the following drugs will require a prescription from a veterinarian as of January 1, 2017, except in cases where a sponsor chooses to voluntarily withdraw the drug application:

Water Soluble Drugs Transitioning From OTC to Rx Status

Established drug name Examples of proprietary drug name(s)
chlortetracycline Aureomycin, Aureomycyn, Chlora-Cycline, Chloronex, Chlortetracycline, Chlortetracycline Bisulfate, Chlortet-Soluble-O, CTC, Fermycin, Pennchlor
erythromycin Gallimycin
gentamicin Garacin, Gen-Gard, GentaMed, Gentocin, Gentoral
lincomycin Linco, Lincomed, Lincomix, Lincomycin, Lincomycin Hydrochloride, Lincosol, Linxmed-SP
lincomycin/spectinomycin* Lincomycin S, Lincomycin-Spectinomycin, L-S, SpecLinx
neomycin Biosol Liquid, Neo, Neomed, Neomix, Neomycin, Neomycin Liquid, Neomycin Sulfate, Neo-Sol, Neosol, Neosol-Oral, Neovet
oxytetracycline Agrimycin, Citratet, Medamycin, Oxymarine, Oxymycin, Oxy-Sol, Oxytet, Oxytetracycline, Oxytetracycline HCL, Oxy WS, Pennox, Terramycin, Terra-Vet, Tetravet-CA, Tetroxy, Tetroxy Aquatic, Tetroxy HCA
penicillin Han-Pen, Penaqua Sol-G, Penicillin G Potassium, R-Pen, Solu-Pen
spectinomycin Spectam
sulfadimethoxine Agribon, Albon, Di-Methox, SDM, Sulfabiotic, Sulfadimethoxine, Sulfadived, Sulfamed-G, Sulforal, Sulfasol
sulfamethazine SMZ-Med, Sulfa, Sulmet
sulfaquinoxaline S.Q. Solution, Sulfa-Nox, Sulfaquinoxaline Sodium, Sulfaquinoxaline Solubilized, Sul-Q-Nox, Sulquin
tetracycline Duramycin, Polyotic, Solu/Tet, Solu-Tet, Supercycline, Terra-Vet, Tet, Tetra-Bac, Tetracycline, Tetracycline Hydrochloride, Tetramed, Tetra-Sal, Tetrasol, Tet-Sol, TC Vet

Note: apramycin, carbomycin/oxytetracycline*, chlortetracycline/sulfamethazine*, streptomycin, sulfachloropyrazine, sulfachlorpyridazine, and sulfamerazine/sulfamethazine/sulfaquinoxaline* are expected to transition to Rx status, but are not marketed at this time. If they return to the market after January 1, 2017, they will require a prescription from a veterinarian.

*Fixed-ratio, combination drug

Current Rx Water Soluble Drugs

Established drug name Examples of proprietary drug names
tylosin Tylan, Tylomed, Tylosin, Tylosin Tartrate, Tylovet

This information is up-to-date as of January 19, 2016. As the industry transitions, CVM anticipates additional changes during the coming months to this information. Please check the Judicious Use of Antimicrobials page for the most recent updates.

Additional Resources