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  1. Science & Research (NCTR)

Tucker A. Patterson Ph.D.
Leadership Role
Deputy Director for Research - National Center for Toxicological Research

Deputy Director for Research, NCTR

Tucker A. Patterson, Ph.D., Deputy Director for Research at NCTR

Tucker A. Patterson, Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov 

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Background

Tucker A. Patterson, Ph.D. is Deputy Director for Research in the Office of the Center Director/Office of Research at the FDA's National Center for Toxicological Research (NCTR). Prior to this appointment, he served two years as the Associate Director for Science & Policy and over seven years as the Associate Director and Health Science Program Manager in Regulatory Compliance & Risk Management at NCTR. Dr. Patterson received a B.S. in Chemistry from the University of Arkansas at Fayetteville and a Ph.D. in Pharmacology from the University of South Carolina. He completed a two-year postdoctoral fellowship with the Center for the Neurobiology of Aging at the University of Florida and continued his postdoctoral training at NCTR through a postgraduate research appointment with the Oak Ridge Institute for Science and Education and as a staff fellow. Dr. Patterson worked for three years as a toxicologist for the State of Arkansas at the Livestock and Poultry Commission prior to returning to NCTR in 2001 where he worked in the Division of Neurotoxicology as a senior scientist.  

Dr. Patterson serves as a primary advisor to the NCTR Center Director for internal and external matters affecting general directions of the NCTR research program. Dr. Patterson’s major responsibilities include directing the NCTR Office of Research, which oversees six research divisions, and serving as NCTR's primary representative on several internal FDA committees and working groups (e.g., Senior Science Council, Research Traineeship Program Working Group, Shared Resources Subcommittee, Research Impact Working Group, One Health Steering Committee, Authorship Dispute Resolution Working Group, etc.). Additional responsibilities include primary representation of NCTR and FDA in extramural activities including research interactions with the State of Arkansas and the NIEHS/National Toxicology Program. 

Research Interests

Dr. Patterson has been involved in neuroscience and neurotoxicology research for more than thirty years and has authored or co-authored more than 100 peer-reviewed scientific articles and book chapters in the areas of pharmacology, toxicology, behavior, and genomics.  His professional scientific activities include the Society of Toxicology (SOT), Society for Sigma Xi, and the International Conference on Neuroprotective Agents. Dr. Patterson serves as a reviewer for many scientific journals in the areas of pharmacology, toxicology, and neuroscience, and has edited numerous books, chapters, and special journal editions.  


Select Publications

“Neuroprotective Effects of Carnitine and its Potential Application to Ameliorate Neurotoxicity.” 
Latham L.E., Wang C., Patterson T.A., Slikker Jr. W., and Liu F.
Chem. Res. Toxicol. – accepted January 10, 2021.

“Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations.” 
Sakkiah S., Guo W., Pan B., Ji Z., Yavas G., Azevedo M., Hawes J., and Patterson T.A. and Hong H.
Front. Chem. 2021, 8:622632. 

“Application of MicroRNA Profiling to Understand Sevoflurane-Induced Adverse Effects on Developing Monkey Brain.” 
Liu F., Gong B., Gu Q., Liu S., Fogle C.M., Patterson T.A., Hanig J.P., Slikker Jr. W., and Wang C.
NeuroToxicology. 2020, 81:172-179. 

“Effects of Xenon-Based Anesthetic Exposure on the Expression Levels of Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) on Human Neural Stem Cell-Derived Neurons.” 
Liu F., Liu S., Patterson T.A., Fogle C., Hanig J.P., Slikker Jr. W., and Wang C. 
Mol. Neurobiol. 2020, 57:217-225. 

“Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models.” 
Liu F., Liu S., Patterson T.A., Fogle C., Hanig J.P., Wang C., and Slikker Jr. W. 
Mol. Neurobiol. 2020, 57:200-207.

“A Potential Role for the Existence of Pericytes in the Neurovascular Unit of the Sexually Dimorphic Nucleus of the Rat Preoptic Area to Control Blood-Brain Barrier Function.”
He Z. and Patterson T.A. 
Curr. Neurovasc. Res. 2019, 16:194-201. doi:10.2174/1567202616666190627120135.

“Lipidomics Reveals Changes in Metabolism, Indicative of Anesthetic-Induced Neurotoxicity in Developing Brains.” 
Wang C., Wang C., Liu F., Rainosek S., Patterson T.A., Slikker Jr. W., and Han X. 
Chem. Res. Toxciol.  2018, 31:825-835. doi:10.1021/acs.chemrestox.8b00186.

“Lipid Profiling as an Effective Approach for Identifying Biomarkers/Adverse Events Associated with General Anesthesia.” 
Wang C., Han X., Liu F., Patterson T.A., Hanig J.P., Paule M.G., and Slikker Jr. W. 
Toxicol. Appl. Pharmacol. 2018, 354:191-195. 

“Evaluation of Dopamine Receptor Integrity After Sevoflurane Exposure in Neonatal Rat Brain Using Positron Emission Tomography.”
Yin Q., Paule M.G., Patterson T.A., Liu F., Fogle C.M., Apana S.M., Berridge M., Slikker Jr. W., Wang C., and Zhang X.
Global J. Anesthesiol. 2018, 5:001-006. doi:10.17352/2455-3476.000040.

“Lipidomics Reveals a Systemic Energy Deficient State that Precedes Neurotoxicity in Neonatal Monkeys after Sevoflurane Exposure.” 
Wang C., Liu F., Frisch-Daiello J.L., Martin S., Patterson T.A., Gu Q., Liu S., Paule M.G., Hanig J.P., Slikker Jr. W., Crawford P.A., Wang C., and Han X.
Analytica Chimica Acta. 2018, 1037:87-96. 


Contact Information
Tucker A. Patterson
(870)543-7121
Expertise
Expertise
Laboratory Methods
Functional Genomics
Neurotoxicology
Toxicology
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