Research Toxicologist — Division of Biochemical Toxicology
Mary D. Boudreau, Ph.D.
Mary Boudreau received bachelor’s and master’s degrees in dietetics and human nutrition, graduating Summa Cum Laude, and a Ph.D. in veterinary medical sciences and toxicology from Louisiana State University. As an undergraduate, she was the recipient of numerous scholastic achievement awards. For her master’s degree program, she examined the role of dietary n-3 fatty acids from fish oil and linolenic acid to suppress the biosynthesis of eicosanoids from arachidonic acid and to alter the arachidonic signaling pathways. As a doctorate candidate, Dr. Boudreau investigated the effects of dietary exposure to mixtures of polycyclic hydrocarbons to alter the toxicity and biochemical effects of the individual components. This work brought into question the interpretation of toxicological data generated from the evaluation of exposures to single compounds, when the actual exposures occur as mixtures. Dr. Boudreau completed her post-doctoral training in biochemical toxicology at the Pennington Biomedical Research Center where she examined the effects of non-steroidal anti-inflammatory drugs on cyclooxygenase signaling and NFkappa activation and demonstrated that tumor suppression by n-3 fatty acids was mediated by cyclooxygenase-independent pathways. After completing her post-doctoral research in 2000, Dr. Boudreau came to NCTR. She is a senior research toxicologist in the Division of Biochemical Toxicology and performs fundamental and applied research in support of the FDA product centers. Dr. Boudreau serves as principal investigator for four National Toxicology Program (NTP)-funded projects and is a recognized expert in toxicology and photobiology.
The perception that dietary supplements are “natural” and therefore safe serves as the first principle for many people who take dietary supplements; however, even the most seemingly benign substances can have significant and entirely unexpected effects. Dr. Boudreau came to NCTR to investigate the potential toxicity and tumor-promoting activities of the cosmetic ingredient and dietary supplement, Aloe Vera, which was the first dietary supplement nominated to the National Toxicology Program (NTP) for regulatory consideration. Dr. Boudreau used her expertise in nutritional toxicology to address the needs of FDA and NTP. Her research on the Aloe Vera plant leaf and other dietary supplements is ongoing. For example, silver is considered a relatively non-toxic metal when ingested by mammals; however, the fate of nano-sized silver particles in biological systems remains a research topic of interest. Dr. Boudreau investigates different sizes of silver nanoparticles to determine the distribution and toxicity potential of these very small particles in biological systems. Topical retinoids are among the most widely used cosmetic ingredients for the mitigation of fine wrinkles and hyperpigmentation in photo- and chronically-aged skin. Many retinoids and other topically applied cosmeceuticals are photosensitizers and may induce skin cancers in the presence of sunlight.
Professional Societies/National and International Groups
Chemical Assessment Advisory Committee (EPA)
2016 – Present
German Federal Institute for Risk Assessment Conference on Nanosilver
Nanomaterials Case Study Workshop (EPA)
Society of Toxicology
2006 – Present
Size- and Coating-Dependent Cytotoxicity and Genotoxicity of Silver Nanoparticles Evaluated Using In Vitro Standard Assays.
Guo X., Li Y., Yan J., Ingle T., Jones M., Mei N., Boudreau M., Cunningham C., Abbas M., Paredes A., Zhou T., Moore M., Howard P., and Chen T.
Nanotoxicology. 2016, 10(9):1373-84.
Intravenous Administration of Silver Nanoparticles Causes Organ Toxicity Through Intracellular ROS-Related Loss of Inter-Endothelial Junction.
Guo H., Zhang J., Boudreau M., Meng J., Yin J., Liu J., and Xu H.
Part Fibre Toxicol. 2016, 13:21.
Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks.
Boudreau M., Imam M., Paredes A., Bryant M., Cunningham C., Felton R., Jones M., Davis K., and Olson G.
Toxicol Sci. 2016, 150 (1):131-60.
Development and Validation of a New Transgenic Hairless Albino Mouse as a Mutational Model for Potential Assessment of Photocarcinogenicity.
Manjanatha M., Shelton S., Chen Y., Gaddameedhi S., Howard P., and Boudreau M.
Toxicol Environ Mutagen. 2015, 791:42-52.
Effects of Subchronic Exposure of Silver Nanoparticles on Intestinal Microbiota and Gut-Associated Immune Responses in the Ileum of Sprague-Dawley Rats.
Williams K., Milner J., Boudreau M., Gokulan K., Cerniglia C., and Khare S.
S.Nanotoxicology. 2015, 9(3):279-89.
Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe Barbadensis Miller (Aloe Vera) in F344/N Rats.
Boudreau M., Mellick P., Olson G., Felton R., Thorn B., and Beland F.
Toxicol Sci. 2013, 131(1):26-39.
Intrinsic Catalytic Activity of Au Nanoparticles with Respect to Hydrogen Peroxide Decomposition and Superoxide Scavenging.
He W., Zhou Y., Wamer W., Hu X., Wu X., Zheng Z., Boudreau M., and Yin J.
Biomaterials. 2013, 34(3):765-73. doi: 10.1016/j.biomaterials.2012.10.010.
Mechanisms of the pH Dependent Generation of Hydroxyl Radicals and Oxygen Induced by Ag Nanoparticles.
He W., Zhou Y., Wamer W., Boudreau M., and Yin J.
Biomaterials. 2012, 33(30):7547-55.
Photocarcinogenesis Study of Retinoic Acid and Retinyl Palmitate [CAS Nos. 302-79-4 (All-Trans-Retinoic Acid) and 79-81-2 (All-Trans-Retinyl Palmitate)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study)
Natl Toxicol Program Tech Rep Ser. 2012, (568):1-352.
Aloe Vera Non-Decolorized Whole Leaf Extract-Induced Large Intestinal Tumors in F344 Rats Share Similar Molecular Pathways with Human Sporadic Colorectal Tumors.
Pandiri A., Sills R., Hoenerhoff M., Peddada S., Ton T., Hong H., Flake G., Malarkey D., Olson G., Pogribny I., Walker N., and Boudreau M.
Toxicol Pathol. 2011, 39(7):1065-74.
Effect of Aloe Vera Whole Leaf Extract on Short Chain Fatty Acids Production by Bacteroides Fragilis, Bifidobacterium Infantis and Eubacterium Limosum.
Pogribna M., Freeman J., Paine D., and Boudreau M.
Lett Appl Microbiol. 2008, 46(5):575-80.
Levels of Retinyl Palmitate and Retinol in the Skin of SKH-1 Mice Topically Treated with Retinyl Palmitate and Concomitant Exposure to Simulated Solar Light for Thirteen Weeks.
Yan J., Xia Q., Wamer W., Boudreau M., Warbritton A., Howard P., and Fu P.
Toxicol Ind Health. 2007, 23(10):581-9.
Photodecomposition of Vitamin A and Photobiological Implications for the Skin.
Fu P., Xia Q., Yin J., Cherng S., Yan J., Mei N., Chen T., Boudreau M. and Howard P.
Wamer WG. Photochem Photobiol. 2007, 83(2):409-24. Review.
Physiological Role of Retinyl Palmitate in the Skin.
Fu P., Xia Q., Boudreau M., Howard P., Tolleson W., and Wamer W.
Vitam Horm. 2007, 75:223-56. Review.
Dietary Exposure to 2-Aminoanthracene Induces Morphological and Immunocytochemical Changes in Pancreatic Tissues of Fisher-344 Rats.
Boudreau M., Taylor H., Baker D., and Means J.
Toxicol Sci. 2006, 93(1):50-61.
An Evaluation of the Biological and Toxicological Properties of Aloe Barbadensis (Miller), Aloe Vera.
Boudreau M. and Beland F.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006, 24(1):103-54. Review.
Suppression of Arylamine Toxicity in the Fischer-344 Rat Following Ingestion of a Complex Mixture.
Boudreau M., Baker D., Taylor H., Barker S., and Means J.
Toxicol Pathol. 2001, 29(3):333-43.
Suppression of Tumor Cell Growth Both in Nude Mice and in Culture by n-3 Polyunsaturated Fatty Acids: Mediation Through Cyclooxygenase-Independent Pathways.
Boudreau M., Sohn K., Rhee S., Lee S., Hunt J., and Hwang D.
Cancer Res. 2001, 61(4):1386-91.
Alpha-Linolenic Acid and Prostaglandin Synthesis.
Boudreau M., Chanmugam P., Hart S., Lee S., and Hwang D.
Nutrition. 1992, 8(3):211-2.
Lack of Dose Response by Dietary n-3 Fatty Acids at a Constant Ratio of n-3 to n-6 Fatty Acids in Suppressing Eicosanoid Biosynthesis from Arachidonic Acid.
Boudreau M., Chanmugam P., Hart S., Lee S., and Hwang D.
Am J Clin Nutr. 1991, 54(1):111-7.
- Contact Information
- Mary Boudreau
- (870) 543-7121
ExpertiseApproachDomainTechnology & DisciplineToxicology