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  1. National Center for Toxicological Research

Jinshan Jin Ph.D.

Jinshan Jin

Visiting Scientist — Division of Microbiology

Jinshan Jin

Jinshan Jin, Ph.D.
(870) 543-7391
NCTRResearch@fda.hhs.gov  

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 About  |  Publications 


Background

Dr. Jin received a Bachelor’s degree in clinical medicine from Norman Bethune University of Medical Sciences (China). She obtained a Ph.D. in molecular genetic and biochemistry from Georgia State University (GSU) and continued with her postdoctoral training at GSU. Her postdoctoral research focused on characterization of potential antimicrobial targets and development of novel antimicrobial agents to combat multidrug-resistant bacteria. Dr. Jin joined NCTR as an ORISE fellow in March 2014, and was recruited as a visiting scientist in NCTR’s Microbiology Division in April 2018.

 
Research Interests

Dr. Jin’s research is primarily focused on using current microbiological and omics techniques to evaluate the toxicities of FDA-regulated products, including smokeless tobacco products, azo dyes, and nanomaterials. She is interested in studying how the interaction between microbiota and FDA-regulated products could affect human health, and ultimately provide data to aid FDA’s risk assessment of products. Dr. Jin has investigated the interaction between smokeless tobacco products on oral microbiota with metagenomic sequencing. She is undertaking a study on the interaction between the skin microbiota and nanomaterials present in sunscreens. Dr. Jin is also interested in developing standard microbiological methods to address FDA’s safety concerns.


Professional Societies/National and International Groups

American Society of Microbiology
Member
2010 - present

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Selected Publications

Smokeless Tobacco Impacts Oral Microbiota in a Syrian Golden Hamster Cheek Pouch Carcinogenesis Model.
Jin J., Guo L., VonTungeln L., Vanlandingham M., Cerniglia C., and Chen H.
Anaerobe. 2018, pii: S1075-9964(18)30095-7. doi: 10.1016/j.anaerobe.2018.05.010. 

Mutation Network-Based Understanding of Pleiotropic and Epistatic Mutational Behavior of Enterococcus faecalis FMN-Dependent Azoreductase.
Sun J., Kweon O., Jin J., He G., Li X., Cerniglia C., and Chen H.
Biochem Biophys Rep. 2017, 12:240-244. doi: 10.1016/j.bbrep.2017.10.008.

Evaluation of Metabolism of Azo Dyes and Their Effects on Staphylococcus aureus Metabolome.
Sun J., Jin J., Beger R., Cerniglia C., and Chen H.
J Ind Microbiol Biotechnol. 2017, 44(10):1471-1481. doi: 10.1007/s10295-017-1970-8.

Biphasic Actions of SecA Inhibitors on Prl/Sec Suppressors: Possible Physiological Roles of SecA-Only Channels.
Hsieh Y., Zhang H., Jin J., Dai C., Jiang C., Wang B., and Tai P.
Biochem Biophys Res Commun. 2017, 482(2):296-300. doi: 10.1016/j.bbrc.2016.11.057.

Effect of Smokeless Tobacco Products on Human Oral Bacteria Growth and Viability.
Liu M., Jin J., Pan H., Feng J., Cerniglia C., Yang M., and Chen H.
Anaerobe. 2016, 42:152-161. doi: 10.1016/j.anaerobe.2016.10.006.

Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria.
Jin J., Hsieh Y., Cui J., Damera K., Dai C., Chaudhary A., Zhang H., Yang H., Cao N., Jiang C., Vaara M., Wang B., and Tai P.
ChemMedChem. 2016, 11(22):2511-2521. doi: 10.1002/cmdc.201600421.

Metabolomics Evaluation of the Impact of Smokeless Tobacco Exposure on the Oral Bacterium Capnocytophaga sputigena.
Sun J., Jin J., Beger R., Cerniglia C., Yang M., and Chen H.
Toxicol In Vitro. 2016, 36:133-141. doi: 10.1016/j.tiv.2016.07.020

Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors.
Cui J., Jin J., Chaudhary A., Hsieh Y., Zhang H., Dai C., Damera K., Chen W., Tai P., and Wang B.
ChemMedChem. 2016, 11(1):43-56. doi: 10.1002/cmdc.201500447

Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus.
Jin J., Cui J., Chaudhary A., Hsieh Y., Damera K., Zhang H., Yang H., Wang B., and Tai P.
Bioorg Med Chem. 2015, 23(21):7061-8. doi: 10.1016/j.bmc.2015.09.027.

SecA: A Potential Antimicrobial Target.
Chaudhary A., Chen W., Jin J., Tai P., and Wang B.
Future Med Chem. 2015, 7(8):989-1007. doi: 10.4155/fmc.15.42. Review.

Design, Syntheses and Evaluation of 4-Oxo-5-Cyano Thiouracils as SecA Inhibitors.
Chaudhary A., Jin J., Chen W., Tai P., and Wang B.
Bioorg Med Chem. 2015, 23(1):105-17. doi: 10.1016/j.bmc.2014.11.017.

Design, Synthesis and Biological Evaluation of Rose Bengal Analogues as SecA Inhibitors.
Cui J., Jin J., Hsieh Y., Yang H., Ke B., Damera K., Tai P., and Wang B.
ChemMedChem. 2013, 8(8):1384-93. doi: 10.1002/cmdc.201300216.
 

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Contact Information
Jinshan Jin
(870) 543-7391