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  1. Science & Research (NCTR)

Jinshan Jin Ph.D.

Visiting Scientist — Division of Microbiology

Jinshan Jin

Jinshan Jin, Ph.D.
(870) 543-7121
NCTRResearch@fda.hhs.gov  

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 About  |  Publications 

Background

Dr. Jin received a bachelor’s degree in clinical medicine from Norman Bethune University of Medical Sciences (China). She obtained a Ph.D. degree in molecular genetics and biochemistry from Georgia State University (GSU) and continued with her postdoctoral training at GSU, focusing on characterization of potential antimicrobial targets and development of novel antimicrobial agents to combat multi-drug resistant bacteria. Dr. Jin joined FDA’s National Center for Toxicological Research (NCTR) as an Oak Ridge Institute for Science and Education fellow in March 2014 and was then recruited as a visiting scientist in NCTR’s Division of Microbiology in April 2018.

Research Interests

Dr. Jin’s research is primarily focused on using current microbiological and omics techniques to evaluate the toxicities of FDA-regulated products, including smokeless tobacco products, azo dyes, nanomaterials, and compounding medicines. She is interested in studying how the interaction between microbiota and FDA-regulated products could affect human health, and ultimately provide data to aid FDA’s risk assessment of products. Dr. Jin has investigated the interaction between smokeless tobacco products on oral microbiota with metagenomic sequencing and she is undertaking a study on the interaction between the skin microbiota and nanomaterials present in sunscreens. Another focus of Dr. Jin’s research is establishing standardized methods for sporicidal efficacy assessment. Her most recent work is characterization of the in vitro cytotoxicity profile of compounded triamcinolone-moxifloxacin drug products. Dr. Jin is also interested in developing standard microbiological methods to address FDA’s safety concerns.

Professional Societies/National and International Groups

American Society of Microbiology
Member
2010 - present


Selected Publications

Phylogenetically Diverse Bacteria Isolated from Tattoo Inks, an Azo Dye-Rich Environment, Decolorize a Wide Range of Azo Dyes.
Nho S.W., Cui X., Kweon O., Jin J., Chen H., Moon Mi., Kim S.J., and Cerniglia C.E.
Annals of Microbiology. 2021, 71:35. doi: 10.1186/s13213-021-01648-2. [Epub Sep 21, 2021].

Thiouracil SecA Inhibitors: Bypassing the Effects of Efflux Pumps and Attenuating Virulence Factor Secretion in MRSA and Bacillus anthracis.
Jin J., Chaudhary A., Hsieh Y.H., Fante B., Wang B., and Tai P.C.
Medicinal Chemistry Research. 2021, 30: 1341-1347. doi: 10.1007/s00044-021-02750-5 [published Jun 10, 2021].

Smokeless Tobacco Impacts Oral Microbiota in a Syrian Golden Hamster Cheek Pouch Carcinogenesis Model.
Jin J., Guo L., VonTungeln L., Vanlandingham M., Cerniglia C., and Chen H.
Anaerobe. 2018, pii: S1075-9964(18)30095-7. doi: 10.1016/j.anaerobe.2018.05.010. 

Mutation Network-Based Understanding of Pleiotropic and Epistatic Mutational Behavior of Enterococcus faecalis FMN-Dependent Azoreductase.
Sun J., Kweon O., Jin J., He G., Li X., Cerniglia C., and Chen H.
Biochem Biophys Rep. 2017, 12:240-244. doi: 10.1016/j.bbrep.2017.10.008.

Evaluation of Metabolism of Azo Dyes and Their Effects on Staphylococcus aureus Metabolome.
Sun J., Jin J., Beger R., Cerniglia C., and Chen H.
J Ind Microbiol Biotechnol. 2017, 44(10):1471-1481. doi: 10.1007/s10295-017-1970-8.

Biphasic Actions of SecA Inhibitors on Prl/Sec Suppressors: Possible Physiological Roles of SecA-Only Channels.
Hsieh Y., Zhang H., Jin J., Dai C., Jiang C., Wang B., and Tai P.
Biochem Biophys Res Commun. 2017, 482(2):296-300. doi: 10.1016/j.bbrc.2016.11.057.

Effect of Smokeless Tobacco Products on Human Oral Bacteria Growth and Viability.
Liu M., Jin J., Pan H., Feng J., Cerniglia C., Yang M., and Chen H.
Anaerobe. 2016, 42:152-161. doi: 10.1016/j.anaerobe.2016.10.006.

Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria.
Jin J., Hsieh Y., Cui J., Damera K., Dai C., Chaudhary A., Zhang H., Yang H., Cao N., Jiang C., Vaara M., Wang B., and Tai P.
ChemMedChem. 2016, 11(22):2511-2521. doi: 10.1002/cmdc.201600421.

Metabolomics Evaluation of the Impact of Smokeless Tobacco Exposure on the Oral Bacterium Capnocytophaga sputigena.
Sun J., Jin J., Beger R., Cerniglia C., Yang M., and Chen H.
Toxicol In Vitro. 2016, 36:133-141. doi: 10.1016/j.tiv.2016.07.020

Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors.
Cui J., Jin J., Chaudhary A., Hsieh Y., Zhang H., Dai C., Damera K., Chen W., Tai P., and Wang B.
ChemMedChem. 2016, 11(1):43-56. doi: 10.1002/cmdc.201500447

Evaluation of Small Molecule SecA Inhibitors Against Methicillin-Resistant Staphylococcus aureus.
Jin J., Cui J., Chaudhary A., Hsieh Y., Damera K., Zhang H., Yang H., Wang B., and Tai P.
Bioorg Med Chem. 2015, 23(21):7061-8. doi: 10.1016/j.bmc.2015.09.027.

SecA: A Potential Antimicrobial Target.
Chaudhary A., Chen W., Jin J., Tai P., and Wang B.
Future Med Chem. 2015, 7(8):989-1007. doi: 10.4155/fmc.15.42. Review.

Design, Syntheses and Evaluation of 4-Oxo-5-Cyano Thiouracils as SecA Inhibitors.
Chaudhary A., Jin J., Chen W., Tai P., and Wang B.
Bioorg Med Chem. 2015, 23(1):105-17. doi: 10.1016/j.bmc.2014.11.017.

Design, Synthesis and Biological Evaluation of Rose Bengal Analogues as SecA Inhibitors.
Cui J., Jin J., Hsieh Y., Yang H., Ke B., Damera K., Tai P., and Wang B.
ChemMedChem. 2013, 8(8):1384-93. doi: 10.1002/cmdc.201300216.

Contact Information
Jinshan Jin
(870) 543-7121
 
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