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  1. Science & Research (NCTR)

Daniel Doerge Ph.D.

Research Biologist — Division of Biochemical Toxicology

Daniel Doerge
Daniel R. Doerge, Ph.D.

(870) 543-7121
NCTRResearch@fda.hhs.gov  

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About  |  Publications  |  Lab Members


Background

Daniel R. Doerge was awarded a bachelor’s degree from Oregon State University and a Ph.D. degree from University of California, Davis. He was then an Assistant Associate Professor of Environmental Biochemistry at the University of Hawaii. Since 1992, he has been a Research Chemist in the Division of Biochemical Toxicology at NCTR.
 

Research Interests

Dr. Doerge’s areas of research specialization include chemical and biochemical mechanisms of toxicity, thyroid toxicology, toxicology of soy isoflavones, acrylamide, bisphenol A and inorganic arsenic. He also specializes in the applications of modern mass spectrometry that emphasize high-throughput determinations of pharmacokinetics and DNA adducts, as well as chemical risk assessment. A common strategy in this food-safety research is the integration of toxicokinetics and human biomonitoring with physiologically-based pharmacokinetic modeling to minimize uncertainty in the extrapolation of human risks from experimental animal toxicity testing. More than 250 peer-reviewed publications have resulted from this work. Dr. Doerge has served on chemical risk-assessment advisory committees for the European Food Safety Authority, World Health Organization, and U.S. Environmental Protection Agency. He has also served as editor-in-chief for Archives of Environmental Contamination and Toxicology
 

Professional Societies/National and International Groups

American Chemical Society
Member
1980 - Present

Division of Chemical Toxicology
Program committee member
2013 - 2014
 

Selected Publications

Pharmacokinetics of Isoflavones from Soy Infant Formula in Neonatal and Adult Rhesus Monkeys.
Doerge D., Woodling K., Churchwell M., Fleck S., and Helferich W.
Food Chem Toxicol. 2016, 92:165-76. Epub 2016 Apr 12.

24-Hour Human Urine and Serum Profiles of Bisphenol A: Evidence Against Sublingual Absorption Following Ingestion in Soup.
Teeguarden J., Twaddle N., Churchwell M., Yang X., Fisher J., Seryak L., and Doerge D.
Toxicol Appl Pharmacol. 2015, 288(2):131-42. Epub 2015 Jan 22.

Using Dietary Exposure and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling in Human Risk Extrapolations for Acrylamide Toxicity.
Doerge D., Young J., Chen J., Dinovi M., and Henry S.
J Agric Food Chem. 2008, 56(15):6031-8. Epub 2008 Jul 15. Review.

Soy Processing Affects Metabolism and Disposition of Dietary Isoflavones in Ovariectomized BALB/c Mice.
Allred C., Twaddle N., Allred K., Goeppinger T., Churchwell M., Ju Y., Helferich W., and Doerge D.
J Agric Food Chem. 2005, 53(22):8542-50.

Quantification of Multiple DNA Adducts Formed Through Oxidative Stress Using Liquid Chromatography and Electrospray Tandem Mass Spectrometry.
Churchwell M., Beland F., and Doerge D.
Chem Res Toxicol. 2002, 15(10):1295-301. 

Anti-Thyroid Isoflavones from Soybean: Isolation, Characterization, and Mechanisms of Action.
Divi R., Chang H., and Doerge D.
Biochem Pharmacol. 1997, 54(10):1087-96.
 

Lab Members


Contact information for all lab members:
(870) 543-7121
NCTRResearch@fda.hhs.gov

Mona I. Churchwell, B.S.
Chemist

Nathan C. Twaddle, B.S.
Chemist


Contact Information
Daniel Doerge
(870) 543-7121
Expertise
Expertise
Approach
Domain
Technology & Discipline
Toxicology
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