Principal Investigator: Amy Goodwin and Kia Jackson
Funding Mechanism: NCTR
ID number: C13070/E0753701
Award Date: 3/31/2014
Institution: National Center for Toxicological Research
Nicotine reduction is a primary strategy for lowering the abuse liability and harm from tobacco products. However, further information regarding the role of nicotine dose in the onset and maintenance of tobacco product use, particularly during adolescence, would be useful. The goal of this project is to examine behavioral and biological effects of nicotine in squirrel monkeys. Researchers will compare two age groups of monkeys (adolescents and adults) with regard to: (1) the acquisition and maintenance of nicotine self-administration; (2) the abuse liability of non-nicotine tobacco product constituents (e.g., myosmine, anatabine); (3) the pharmacokinetics of nicotine and other tobacco product constituents; and (4) the neurochemical alterations associated with nicotine and other tobacco product constituents, measured using imaging techniques. Study findings may improve methods for assessing the biological and behavioral effects of exposure to chemicals found in tobacco products and may provide data regarding the impact of nicotine reduction.