Science & Research

System for Magnetic Resonance Spectroscopy of Brain Tissue for Pattern-based Diagnostics

Available for licensing and commercial development is a system for preprocessing magnetic resonance spectroscopy (MRS) data of brain tissue for pattern-based diagnostics. The MRS preprocessing system includes an MRS preprocessing module that executes an operation that normalizes MRS spectrum data, recalibrates and scales the normalized MRS spectrum data, and then renormalizes the scaled MRS spectrum data. The resulting preprocessed MRS data is used to assist in identifying abnormalities in tissues shown in MRS scans. Raw MRS spectrum data and scaling the raw MRS spectrum data is achieved by a plurality of weighting constants to generate a preprocessed MRS spectrum data. The method may also include providing raw MRS spectrum data, recalibrating the raw MRS spectrum data, and scaling the recalibrated MRS spectrum data by using a plurality of weighting constants to generate a preprocessed MRS spectrum data.

Potential Commercial Applications:

  • MRI Imaging
  • Brain Imaging
  • Neurology

Competitive Advantages:


Jon Wilkes
Dan Buzatu
Pierre Alusta
Bruce Pearce
Ryan Kretzer
Inessa Im
Richard Beger

Intellectual Property:
US Patent No. 8,880,354
PCT Application No. PCT/US10/56486

Collaboration Opportunity:
The FDA National Center for Toxicological Research is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize FDA’s magnetic resonance spectroscopy technology in various imaging and diagnostic applications. Please contact Alice Y. Welch, Ph.D. at 301-796-8449 or for more information.

Licensing Contact:
Bill Ronnenberg, JD-MIP, MS
FDA Technology Transfer Program
10903 New Hampshire Ave.
Building WO1, Rm 4214
Silver Spring, MD 20993
Phone: 240-402-4561

OTT Reference No: E-298-2009/0
Updated: August 12, 2015

Page Last Updated: 03/19/2018
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