Science & Research

FDA Grand Rounds

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The FDA Grand Rounds is an educational presentation that is webcast monthly to highlight cutting-edge research underway across the Agency and its impact on protecting and advancing public health. Each session features an FDA scientist presenting on a key public health challenge and how FDA is applying science to its regulatory activities. The 45-minute educational presentation is followed by questions from the audience.  #FDAGrandRounds.

Thursday, November 8, 2018
12:00 p.m. - 1:00 p.m. EST

Presented by  

Randy Self
Research Chemist
Applied Technology Center
FDA's Office of Regulatory Affairs
Pacific Northwest Laboratory

Webcast Lecture 

 Decomposition of Seafood Products by Mass Spectrometry with Sensory-Driven Predictive Modeling

About the Presentation

Sensory analysis is performed in FDA testing laboratories to determine the decomposition status of seafood samples. Current methodology to complement this testing with chemical analysis (e.g., histamine) is not always directly comparable to sensory testing.

The presentation will discuss a novel method that FDA is exploring with untargeted analysis and a statistical model driven by sensory results via a script written in the R programming language. This enables generation of data that are directly comparable to commonly used sensory scoring techniques.

The method was applied to six species of salmon, across a wide range of decomposition conditions. Accuracy and reproducibility of the method in comparison with sensory results were demonstrated, and show promising results. Since it generates data which are comparable to sensory analysis, it provides a potentially useful companion to that work. Implementation of this technique stands to open an additional avenue for this type of analysis, aiding the agency’s public health mission with increased coverage of this issue. 

About the Presenter 

Randy Self is a research chemist with FDA’s Applied Technology Center in the Pacific Northwest Laboratory, where he conducts research on method development for food safety applications. His work focuses primarily on development of novel high-resolution mass spectrometry techniques.  Randy has been with FDA since 2001, serving as a regulatory chemist at the Pacific Northwest Laboratory before joining the Agency's Applied Technology Center.  

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Past Grand Rounds





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