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U.S. Department of Health and Human Services


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Lactated Ringer

Detailed View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) – October 2011


Summary View


Lactated Ringer’s injection in aviva plastic container

Lactated Ringer’s in viaflex plastic container

Lactated Ringer’s and 5% Dextrose in viaflex plastic container

Sodium Lactate (M/6 sodium lactate) injections in viaflex plastic container



  • Excessive administration of Sodium Lactate Injection, USP may result in hypokalemia



  • Do not connect flexible plastic containers in series in order to avoid air embolism due to possible residual air contained in the primary container
  • The osmolarity of Sodium Lactate Injection, USP is 334 mOsmol/L (calc). Administration of substantially hypertonic solutions may cause venous irritation, including phlebitis



Class Reactions
  • Other manifestations of hypersensitivity/infusion reactions: decreased heart rate, tachycardia, blood pressure decreased.....