For Industry

Orphan Products Natural History Grants Program

The Office of Orphan Products Development (OOPD) is proud to announce the launch of a new grant program to fund targeted natural history studies for rare diseases. OOPD plans to fund approximately $2M in FY 2017 to award 2-5 grants for natural history studies targeted on expediting the development of products for these rare conditions.

The goal of the Orphan Products Natural History Grants Program is to support studies that advance rare disease medical product development through characterization of the natural history of rare diseases/conditions, identification of genotypic and phenotypic subpopulations, and development and/or validation of clinical outcome measures, biomarkers and/or companion diagnostics.

Receipt Dates

October 14, 2016

Anticipated Spring 2019 - Please check back periodically for updates.

Funding Levels:

Prospective Natural History Studies:

  • Maximum of $400,000 in total cost per year for up to five years

Retrospective Natural History Studies or Survey Studies:

  • Maximum of $150,000 in total cost per year for up to two years

For more detailed information on the OOPD Grant Program, please review the following:

General Information

Request for Applications (RFA) and Instructions:

Federal Registerdisclaimer icon (Abbreviated Version) 
NIH Guide
Notice of Cancellation of the October 2018 Receipt Date

Application Instructions

 Other Useful Links:


Page Last Updated: 03/14/2018
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