Select Committee on GRAS Substances (SCOGS) Opinion: Sodium thiosulfate

The GRAS Substances (SCOGS) Database allows access to opinions and conclusions from 115 SCOGS reports published between 1972-1980 on the safety of over 370 Generally Recognized As Safe (GRAS) food substances. The GRAS ingredient reviews were conducted by the Select Committee in response to a 1969 White House directive by President Richard M. Nixon.

Sodium thiosulfate

  • SCOGS-Report Number: 52*
  • Type Of Conclusion: 1
  • ID Code: 10102-17-7
  • Year: 1975
  • 21 CFR Section: 184.1807

SCOGS Opinion:

Thiosulfate is a normal constituent fo human body fluids, and is a metabolite of dietary constituents. Experimental animal studies show that sodium thiosulfate is well tolerated. All investigations in which it has been administered to normal and diseased persons, clearly show that very large therapeutic doses cause no adverse effects. The reported use of sodium thiosulfate as a stabilizer of potassium iodide salt, as a sequestrant in alcoholic beverages, and as a substance that may migrate to foods from packaging materials, results in human exposure far below that needed to produce untoward biological effects.

The Select Committee has weighed the foregoing and concludes that:

There is no evidence in the available information on sodium thiosulfate that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when it is used at levels that are now current or that might reasonably be expected in the future.

*Complete reports containing details of the safety studies that formed the basis of the opinions and conclusions and are available from the National Technical Information Service (NTIS), 5285 Port Royal Road, Springfield, VA 22161 (703) 605-6000.

Page Last Updated: 10/16/2015
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