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U.S. Department of Health and Human Services


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AASLD-FDA-NIH-PhRMA Hepatotoxicity Steering Group Meeting, 2006 Presentations

Session I. Non-Clinical Prediction (Patrick Wier, Moderator)
Can pre/non-clinical studies really predict that a drug will be hepatotoxic to people?

Session I Questions and Answers [PDF]


Session II. Liver Adaptation to Injury (Paul Watkins, Moderator)
How does the liver adapt to xenobiotic injury and become tolerant?

Session II Questions and Answers [PDF]


Session III. Attribution of Causality (Len Seeff, Moderator)
How likely is it that a drug really caused the injury, and if so which drug?

Session III Summary [PDF]