R. W. Johnson Pharmaceutical Research Institute

Carbonic Anhydrase Inhibitors

Teratogenic in Animals

Acetazolamide Yes (Rat, Mouse, Rabbit, Hamster)

Benzolamide No

Dichlorphenamide Yes (Rat, Mouse)

Ethoxzolamide Yes (Rat)

Methazolamide Yes (Rat)

“In general, human use of diuretics during pregnancy has demonstrated no strong evidence associating them with congenital abnormalities”

Schardein JL (1993). Diuretics. In: Chemically Induced Birth Defects. Marcel Dekker, Inc., New York, pp. 80-85.