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| Hydroquinone is one of the most effective molecules for the treatment of dark discoloration over the past 40-50 years and has been used in millions of people. In 23 years of practice, I have never had a patient have an adverse reaction other than mild irritation, and countless patients have been infinitely grateful for the improvement in their skin that hydroquinone has given them. Hydroquinone has been a safe and effective treatment among patients with concerns including melasma, photo-aging, and post-inflamatory hyperpigmentation. Since 1961, hydroquinone has demonstrated a safe and effect profile among clinicians prescribing or recommending hydroquinone. In spite of humans exposure to natural sources of hydroquinone in various foods and beverages, there is not an association with carcinogenicity. There have been no reported cases of related malignancies in more than 50 years of manufacture and use of hydroquinone.
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