2005P-0267 Remove from label for propofol (Diprivan) the warning that propofol should be administered only by trained persons
FDA Comment Number : EC165
Submitter : Dr. Ali Afrassiabi Date & Time: 11/17/2005 01:11:20
Organization : Dr. Ali Afrassiabi
Category : Health Professional
Issue Areas/Comments
GENERAL
GENERAL
I use propofal every day. Frequently this use is in very small doses, to allow the injection of a local anesthetic. Although dosing suggestions are made by the manufacturer, every single patient seem to have a different response and dose requirement. Many people become apenic and desaturate rapidly, i.e are under a general anesthtetic, even with a dose of Propofal that is well below the recommended dose by the manufacturer to achieve induction of a general anesthetic. This is a situation that can be extremely dangerous if the person adminitering Propofal is not fully trained in genral anestheisa and advanced Airway Mangement. I urge the FDA to continue its policy of limiting the use of Propofal to professionals trained in General Anesthesia.

Sincerely Yours'

Ali Afrassiabi, MD
Gig Harbor, WA