Docket Number 02P-0317From: Dieterich, Lauren [LDieterich@kellencompany.com] Sent: Tuesday, June 21, 2005 4:19 PM To: Dockets, FDA Subject: Docket Number 02P-0317 June 21, 2005 Division of Dockets Management Food and Drug Administration Dept. HHS 5630 Fishers Lane, Rm. 1061 Rockville, MD 20852 RE: Docket Number 02P-0317 The Massachusetts Institute of Technology is known for its Nobel prize-winning staff and excellence in science and math. In 1998, scientists at MIT’s Clinical Research Center conducted a study, which concluded that aspartame is safe for the general population: “Mood, aggression and selected cognitive functions were tested during a study in which some of the subjects consumed doses of aspartame nearly 20 times the daily amount taken by the vast majority of the general population. Even daily large doses of aspartame had no adverse effect on study subjects' health and well being, Despite the high consumption of aspartame, the 48 normal subjects showed no changes in mood, memory, behavior, electroencephalograms (which record the electrical signals of the brain) or physiology that could be tied to aspartame. Although some subjects reported headaches, fatigue, nausea and acne, the same number of incidences were reported by subjects taking placebo and sugar as those taking aspartame.” Dr. Spiers, the study’s author, notes that these findings support the results of another recent study with preschool and elementary age children that discovered no effect on their moods, activity levels, behavior or thinking after they consumed high doses of aspartame. Please see the attached .pdf for additional information regarding this study. Respectfully submitted, Lyn O’Brien Nabors Executive Vice President Calorie Control Council <>