2002P-0122
  

  

  


  

  

  


  

  
FDA Comment Number : 
  

  
EC13
  



  

  
Submitter : 
  

  
Ms. MB Brennan
  

  
Date & Time: 
  

  
01/19/2007 02:01:43
  



  

  
Organization : 
  

  
Ms. MB Brennan
  



  

  
Category : 
  

  
Individual Consumer
  



  

  
Issue Areas/Comments 
  


  

  


  

  
GENERAL
  


  

  



  

  
GENERAL
  


  

  



  

  
 Good afternoon,   



I'm concerned that the FDA is permitting wildly experimental things such as cloned foods, yet can't see that conventional foods have real benefits besides protein, fat, carbs and calories.  Remember Dolly, the first cloned animal died with several diseases.  I must object to the use of cloned meats until volumes and decades of research have shown it is safe.



There are numerous federally-supported studies which show benefits of food components or chemicals that exist in conventional foods.  Can someone actually sit and review those studies that are already published on Pubmed.gov and figure out how to make us healthier?  I3C is found in cruciferous vegetables.  It was in ~ 200 BC that Cato the Elder first mentioned the benefit of cabbage leaves in his Book written to his son (On Farming): De Agricultura!!  That book exists now in two translations that I found in the NYU Bobst library.  There he states that the most pungent type of cabbage has the most benefit.



Another Example, if one types into the PUBMED search engine 'indole 3 carbinol & cancer or I3C and cancer'  there are an incredible amount of studies brought forth.



See the following  pasted from that website:  My NCBI  

 

All Databases PubMed Nucleotide Protein Genome Structure OMIM PMC Journals Books 

 

   All: 20    Review: 1   Items 1 - 20 of 20 One page. 



1:  Rahman KM, Sarkar FH, Banerjee S, Wang Z, Liao DJ, Hong X, Sarkar NH. Related Articles, Links  

 Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model.

Mol Cancer Ther. 2006 Nov;5(11):2747-56. 

PMID: 17121921 [PubMed - in process] 

2:  Kim DS, Jeong YM, Moon SI, Kim SY, Kwon SB, Park ES, Youn SW, Park KC. Related Articles, Links  

 Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells.

Cell Mol Life Sci. 2006 Nov;63(22):2661-8. 

PMID: 17086378 [PubMed - indexed for MEDLINE] 

3:  Hsu JC, Dev A, Wing A, Brew CT, Bjeldanes LF, Firestone GL. Related Articles, Links  

 Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.

Biochem Pharmacol. 2006 Dec 15;72(12):1714-23. Epub 2006 Sep 12. 

PMID: 16970927 [PubMed - in process] 


  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  


  

  








  

  
 4:  Moiseeva EP, Heukers R, Manson MM. Related Articles, Links  

 EGFR and Src are involved in indole-3-carbinol-induced death and cell cycle arrest of human breast cancer cells.

Carcinogenesis. 2006 Sep 6; [Epub ahead of print] 

PMID: 16956907 [PubMed - as supplied by publisher] 

5:  Sundar SN, Kerekatte V, Equinozio CN, Doan VB, Bjeldanes LF, Firestone G



I seriously propose that the FDA look into the differences and benefits of varieties of foods such as organic versus conventional foods. Also to see which food components can really help people with heart, cancer, asthma and other problems.  Can someone actually sit and review those studies that are already published on Pubmed.gov and figure out how to make us healthier?



Sincerely,

MB Brennan