From: BULLELKMAN@aol.com
Sent: Tuesday, July 01, 2003 2:01 AM
To: fdadockets@oc.fda.gov
Subject: Docket No. 2003N-0169 - Dental Mercury Amalgam Informat
Dear FDA,

Below you will find additional scientific studies for the new panel to review.

It is vital that the new panel realize how important this issue of mercury dental fillings is to the health and well being of millions and millions of Americans.

Thank you for finally doing your job and start working to protect Americans from these toxic mercury dental fillings.  

Thank you,
Mary Ann Newell
Vancouver, WA 

Neurobehavioral effects from exposure to dental amalgam Hg0: new distinctions between recent exposure and Hg body burden. Echeverria D, et al. (1998).  FASEB J. 12:971-980. 

Behavioral effects of low-level exposure to Hg0 among dental professionals: a cross-study evaluation of psychomotor effects. Bittner et al., (1998). Neurotoxicol. Teratol. 20:429-439. 

Behavioral effects of low-level exposure to elemental Hg among dentists. Echeverria et al., (1995). Neurotoxicol. Teratol. 17:161-168.

Chronic neurobehavioural effects of elemental mercury in dentists. Ngim et al., (1992). Br. J. Ind. Med. 49:782-790. 

The relationship between mercury from dental amalgam and mental health. Siblerud (1989). Am. J. Psychother. 43:575-587.

Chronic elemental mercury intoxication: neuropsychological follow-up case study. Hua et al., (1996). Brain Inj. 10:377-384. 

Mercury vapor inhalation inhibits binding of GTP to tubulin in rat brain: similarity to a molecular lesion in Alzheimer diseased brain. Pendergrass et. al., (1997). Neurotoxicology 18:315-324.

Inhibition of brain tubulin-guanosine 5'-triphosphate interactions by mercury: similarity to observations in Alzheimer's diseased brain. Pendergrass and Haley (1997). Met. Ions Biol. Sys. 34:461-478.

Increased blood mercury levels in patients with Alzheimer's diseases. Hock et. al., (1998). J. Neural. Transm. 105:59-68.

Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease. Basun et. al., (1991). J. Neural Transm. Park. Dis. Dement. Sect. 3:231-258.

Brain trace elements in Alzheimer's disease. Ehmann et. al., (1986). Neurotoxicology 7:195-206.

Regional brain trace-element studies in Alzheimer's disease. Thompson et. al., (1988). Neurotoxicology 9:1-7.

Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains. Wenstrup et. al., (1990). Brain Res. 533:125-131.

Trace element imbalances in hair and nails of Alzheimer's diseases patients. Vance et. al., (1988). Neurotoxicology 9:197-208.

Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain. Cornett et. al., (1998). Neurotoxicology 19:339-345.

Evidence that mercury from silver dental fillings may be an etiological factor in multiple sclerosis. Siblerud and Kienholz (1994). Sci. Total Environ. 15:191-205. 

A comparison of mental health of multiple sclerosis patients with silver/mercury dental fillings and those with fillings removed. Siblerud (1992). Psychol. Rep. 70:1139-1151.

Amyotrophic lateral sclerosis after accidental injection of mercury. Schwarz et al., (1996). J. Neurol. Neurosurg. Psychiatry 60:698. 

Relationship between exposure to environmental toxins and motor neuron disease: a case report. Vanacore et al., (1995). Med. Lav. 86:522-533. 

Amyotrophic lateral sclerosis and mercury-preliminary report. Mano et. al., (1990). Rinsho Shinkeigaku 30:1275-1277

Trace element imbalances in amyotrophic lateral sclerosis. Khare et. al., (1990). Neurotoxicology 11:521-532.

Mercury in hair of patients with ALS. Mano et. al., (1989). Rinsho Shinkeigaku 29:844-848.

Mercury intoxication simulating amyotrophic lateral sclerosis. Adams et al., (1983). JAMA 250:642-643. 

Inorganic mercury intoxication reminiscent of amyotrophic laterial sclerosis. Barber (1978). J. Occup. Med. 20:667-669. 

The enigma of parkinsonism in chronic boderline mercury intoxication, resolved by challenge with pencillamine. Finkelstein et al., (1996). Neurotoxicology 17:291-295. 
Toxicological and neurophysiological findings in patients presenting to an environmental toxicology service. Koppel and Fahron (1995). J. Toxicol. Clin. Toxicol. 33:625-629

Imbalances of trace elements related to oxidative damage in Alzheimer's diseases brain. Cornett et. al., (1998). Neurotoxicology 19:339-345

Demonstration of mercury in the human brain and other organs 17 years after metallic mercury exposure. Opitz et al., (1996). Clin. Neuropathol. 15:139-144.

Entry of low doses of mercury vapor into the central nervous system. Pamphlett and Coote (1998). Neurotoxicology 19:39-47.

Acute and chronic neuropsychological consequences of mercury vapor poisoning in two elderly adolescents. Yeates and Mortensen (1994). J. Clin. Exp. Neuropsychol. 16:209-222

Psychometric evidence that mercury from silver dental fillings may be an etiological factor in depression, excessive anger, and anxiety. Siblerud et al., (1994). Psychol. Rep. 74:67-80. 

Behavioral consequences of in-utero exposure to mercury vapor. Newland et al., (1996). Toxicol. Appl. Pharmacol. 139:374-386. 

Behavioral effects of neonatal metallic mercury exposure in rats. Frederickson et. al., (1992). Toxicology 74:151-160

Effect of subchronic mercury exposure on electrocorticogram of rats. Desi et al., (1996). Neurotoxicology 17:719-723
. 
Neurological abnormalities associated with remote occupational elemental mercury exposure. Albers et. al., (1988). Ann. Neurol. 24:651-659

Psychological effects of low exposure to mercury vapor: application of a computer-administered neurobehavioral evaluation systerm. Liang et al., (1993). Environ. Res. 60:320-327

Uptake of inorganic mercury in the olfactory bulbs via olfactory pathways in rats. Henriksson and Tjalve (1998). Environ. Res. 77:130-140

A stereological study of dorsal root ganglion cells and nerve root fibers from rats exposed to mercury vapor. Schionning et al., (1998) Acta Neuropathol. 96:185-190

Mercury in the rat hypothalamic arcuate nucleus and median eminence after mercury vapor exposure. Ernst et al., (1993). Exp. Mol. Pathol. 58:205-214.

Detection of mercury in rat spinal cord and dorsal root ganglia after exposure to mercury vapor. Schionning et al., (1993). Exp. Mol. Pathol. 58:215-228.

Oxidative damage to nucleic acids in motor neurons containing mercury. Pamphlett et al., (1998). J. Neurol. Sci. 159:121-126. 

Pathological changes in the Brown Norway rat cerebellum after mercury vapour exposure. Hua et al., (1995). Toxicology 104:83-90. 

The effect of mercury vapour on cholinergic neurons in the fetal brain: studies on the expression of Nerve Growth Factor and its low- and high- affinity receptors. Sodestrom et al., (1995). Brain Res. Dev. Brain Res. 85:96-108. 

Mercury distribution in cortical areas and fiber systems of the neonatal and maternal adult cerebrum after exposure of pregnant squirrel monkeys to mercury vapor. Warfvinge et al., (1994). Environ. Res. 67:196-208.

Metallothionein induction in fetal rat brain and neonatal primary astrocyte cultures by in utero exposure to elemental mercury vapor (Hg0). Aschner et al., (1997). Brain Res. 778:222-232. 

An epidemiologic study of the relation between symptomss of fatigue, dental amalgam and other factors. Michel et. al., (1989). Swed. Dent. J. 13:33-38.

Does mercury from amalgam restorations constitute a health hazard. Weiner et al., (1990). Sci. Total Environ. 99:1-22.