From: OC EXECSEC Sent: Tuesday, June 12, 2001 10:08 AM To: Dockets, FDA Subject: FW: Do Not Approve A/F Protein's Genetically Engineered Fish--Docket# 01P-0230 -----Original Message----- From: Lise Smith [mailto:smithpeters@prodigy.net] Sent: Tuesday, June 12, 2001 8:06 AM To: Commissioner Subject: Do Not Approve A/F Protein's Genetically Engineered Fish--Docket# 01P-0230 Commissioner , I am writing to let you know that I am extremely against the possible commercialization of genetically engineered fish. I urge the FDA not to approve the current application by A/F Protein to sell GE Salmon. If one of those fish gets out of the pen, the whole species of real salmon can be harmed. We should not be playing god in creating ge animals or food. Genetically engineered fish have the potential to be invasive species that could cause irreversible ecological damage to wild fish stocks as well as the wider marine environment. Sterility of genetically engineered fish is inherently uncertain given the possibility for human error and natural variation. Even if sterility were ever achievable, sterile genetically engineered fish would still compete with wild fish for food, habitat and will effect the overall marine ecology. The history of fish farming clearly demonstrates that once released into ocean ponds, fish will escape and, since fish do not obey national boundaries, any release of genetically engineered fish will be international by its very nature. The release of GE fish is an international concern in which we all have a stake and on which every government and their citizens should have an opportunity to say no. I urge the FDA not to approve the current application by A/F Protein for GE Salmon because GE fish pose an unnecessary and unacceptable risk to the marine environment and potentially to human health. Lise Smith 1406 Fern Ave. McAllen, TX 78501 USA smithpeters@prodigy.net