From: StuFlash@aol.com Sent: Thursday, January 11, 2001 1:35 PM To: EXECSEC Subject: Antibiotic use in agriculture I am writing to express my concern over the potential effects of the extensive use of antibiotics in animal feeds. As you are, I'm sure, aware, agribusiness currently uses large amounts of antibiotics as components of livestock feeds. They do this because the evidence indicates that adding antibiotics results in increased weight gain by the animals, and hence more profit for the producer. However, this practice is creating a serious risk to human health & safety. As I am sure you are also aware, the prevalence of antibiotic resistance among human pathogens has increased dramatically in recent years. While there are probably a number of other factors involved, such as overuse of antibiotics on human patients, the extensive use of antibiotics in agriculture must be considered a prime suspect. I urge the Food and Drug Administration to begin to address this problem. While I recognize it may be premature to institute an outright ban on antibiotic use in animal feeds, at the very least the FDA should begin to monitor antibiotic use in agriculture, including requiring reporting the amounts and types and locations of antibiotic use in animal feeds. The FDA should also consider, in cooperation with the Department of Agriculture, instituting monitoring of antibiotic resistance in livestock-associated microbial populations, especially for microbes that either can transmit disease to humans or that can readily exchange genetic information with human pathogens. Sincerely, Stuart M. Flashman, Ph.D. (molec. biol.), J.D. 5626 Ocean View Drive Oakland, CA 94618-1533 (510) 652-5373