From: EXECSEC
Sent: Wednesday, December 06, 2000 8:13 AM
To: Dockets, FDA
Subject: FW: LOTRONEX



-----Original Message-----
From: Henney, Jane 
Sent: Wednesday, December 06, 2000 8:10 AM
To: EXECSEC
Subject: FW: LOTRONEX




> ----------
> From: 	-
> Sent: 	Wednesday, December 06, 2000 8:04:10 AM
> To: 	JHENNEY@OC.FDA.GOV
> Subject: 	LOTRONEX
> Auto forwarded by a Rule
> 
> 
> 


Dear Doctor Henney:

	I am writing to let you know how incredibly upset I am about the removal
of LOTRONEX from the market.  This drug gave me my life back!  For over
15 years I suffered on a daily basis.  Six months ago I was put on
LOTRONEX and immediately I felt the difference.  I was a whole person
again…I felt great!  This drug empowered me to live a normal life,
something I had not done in many many years.  I can’t believe it’s being
taken away from me!

	Although the drug was prescribed for  my irritable bowel symptoms,  the
major benefit that I experienced was that my migraines virtually
disappeared.  Life with migraines is a horrible nightmare.  I was
averaging 10 IMITREX shots a month before LOTRONEX.  When I started
taking LOTRONEX, my IMITREX usage went down to 1 shot a month--a
wonderful side effect of the drug!  I felt so good, better than I have in
over 15 years.
 
	My debilitating migraine symptoms didn’t come when I took the LOTRONEX. 
It was wonderful.  And, the irritable bowel symptoms were greatly
reduced.  When I did have constipation I took a magnesium supplement
(250mg-750mg) as needed.  It worked beautifully.

	Isn’t there some way this drug can be returned to the market?  Can it be
reformulated with magnesium to help with the constipation?   Is it
possible for some people who had great success with the drug to keep on
getting it if their doctor okays it? 
My doctor said he would sign any paperwork for me to keep getting
LOTRONEX.  

	I have not had LOTRONEX for 4 days now and I feel significantly worse. 
My body is in pain, my head feels swollen, and my spirit is crushed.  I
feel like my health has been ruined- and my life taken away from me. 
This was a wonderfully effective drug.  I don’t know where to turn now. 
Can you help me?  Is there a way for me to continue taking LOTRONEX? 
Anything you can do will be greatly appreciated

	Thank you,