CPCRA GART Study (046) A Randomized Study of Antiretroviral Management Based on Plasma Genotypic Antiretroviral Resistance Testing (GART) in Patients Failing Antiretroviral Therapy

7/25/00


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Table of Contents

CPCRA GART Study (046) A Randomized Study of Antiretroviral Management Based on Plasma Genotypic Antiretroviral Resistance Testing (GART) in Patients Failing Antiretroviral Therapy

Study Design

Algorithm For Interpretation Of Resistance Mutations: RTIs

Algorithm For Interpretation Of Resistance Mutations: PIs

Baseline GART Report

Baseline Characteristics

Distribution of Major Mutations

Impact of GART Report on Regimen Prescribed in the GART Group

HIV RNA (log10) Change from Baseline

Mean HIV RNA by Study Week

Percent of Patients with Undetectable HIV RNA, by Study Week

HIV RNA Changes by Number of Active Drugs Prescribed

No. Drugs Prescribed by Randomization Group

PPT Slide

PPT Slide

PPT Slide

Change in HIV RNA (from Baseline to Average of 4 and 8 Weeks) Associated with Selected Protease Mutations

Conclusion

Conclusions (continued)

Protocol Team

Author: Lee Kubiak