UFT® Development

10/12/99


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Table of Contents

UFT® Development

UFT®

UFT®

Tegafur

Discontinuation in U.S. of Oral Tegafur Development

Combination of Uracil and Tegafur (UFT)

UFT Clinical Experience in Japan

UFT® plus Leucovorin Calcium

Clinical Pharmacology Studies

Clinical Pharmacology Summary

UFT/LV: Phase I Studies

UFT/LV: Phase II Studies Efficacy

UFT/LV: Phase II Studies Grade 3-4 Toxicities

Leucovorin Dose

Regimen for Phase III

Author: Bristol-Myers Squibb Pharmaceutical Research Institute