Mortality in SAH Safety Studies without a Vehicle Control
Three studies were performed to compare safety across dose levels of tirilazad.
- Study 62: men only; 6 vs. 10 mg/kg/day
- Study 55: men and women; 6 vs. 10 vs. 15 mg/kg/day
- Study 56: men and women; 10 vs. 15 mg/kg/day
In study 55, there was an excess mortality risk in the highest dose group: