Aggrenox: Confirmatory Evidence?

• ESPS1

  • tested combination of immediate release dipyridamole 75 mg + aspirin 330 mg three times daily vs. placebo for 24 months
  • protocol not uniform

• U88-0473

  • tested combination of dipyridamole 75 mg + aspirin 330 mg versus dicoumarol
  • small study (137 patients)
  • few events

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