Division Of Antiviral Products Advisory Committee Meeting

Antiretroviral Armamentarium:
Integrase Inhibitor

ÞIntegrase is one of three HIV-1 enzymes required for viral replication

ÞResults in integration of HIV-1 DNA into host cell genome

ÞRaltegravir targets viral integrase

•blocks strand transfer step, thus inhibiting viral replication


	Integrase is 1 of 3 enzymes necessary for HIV-1 viral replication. Integrase allows for the integration of HIV-1 DNA into the genome of the host cell. Raltegravir targets this enzyme and blocks strand transfer that is necessary for viral replication.