|Viruses from 5
subjects failing MVC treatment with CCR5 tropic virus showed evidence of a
lower plateau in maximum percentage inhibition rather than fold changes in
|The results support
previous findings from selection of MVC-resistant virus in cell culture and
isolates from Phase 2 MVC studies that lower plateaus in the maximum
percentage inhibition (MPI) were associated with subjects failing a
MVC-containing regimen rather than changes in EC50 values.
|All 5 subjects had
amino acid changes in the V3 loop of gp120 which were present at failure
timepoints but were not present at BL.
|•These 5 subjects also had lower Cmin values <75