|•28 subjects failed with CXCR4 virus and were followed by
the sponsor, 20 had at least one follow-up visit.
|2/3 had changed
tropism back to CCR5 or dual-mixed and 35% still had X4-tropic virus
|For the subjects
with R5- or dual/mixed-tropic virus at end of follow-up, the median time to
last follow-up was approximately 5 months (range 18 days to 8 months).
|In contrast, the
follow-up time for the subjects who remained X4-tropic at the last follow-up
visit was one month or less (median time was approximately 11 days).
|•Suggesting that over a longer period of follow-up, CCR5
viruses will outgrow X4 viruses in these subjects
|In half of the
subjects, CD4 cell counts also declined (mean change -21, median change -3)
consistent with the ongoing viremia.