•No increase in mortality or malignancy
observed
•
•No clear evidence of hepatotoxicity, but this was a complicated patient
population with a high rate of liver abnormalities at baseline.
•
•Infections
–No evidence of increase overall
–Possible increase in Candida, Herpes, and influenza infections
–
•Possible increase in cardiac ischemic events
•
•Possible increase in myositis
•
•Mild increase in total cholesterol and LDL
levels
•