13
Drug Safety and Risk
Management Advisory Committee
February 9, 2006
Stimulants
nUsed for decades
nPrinciple compounds in use currently:
qAmphetamines
nAdderall = 25%
l-amphetamine, 75% d-amphetamine
nDextroamphetamine
qMethylphenidate and d-methylphenidate
nAvailable in extended release formulations
nAdverse effects: abuse/dependence (Schedule C-II), tics, cardiovascular, CNS, growth
nAdderall XR approved for adult ADHD