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•Study Design Limitations
–Possible viral or parasitic etiology for symptom
definitions
–High risk groups
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•Study Design Strengths:
–All studies used techniques to control for clustering
–All studies measured baseline hygiene information
•Hygiene practices over duration of the study (n=1)
•Product monitoring (n=2)
–Three studies masked participants and/or
interviewers
•Use of a placebo plain soap (n=3)
–Extensive follow-up for symptoms
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