1
RESIST Trials - Grade 3 or 4 AST, ALT or Total Bilirubin:
Actions and Outcomes
CPI/r
N=737
TPV/r
N=748
Action Taken:
26 (3.5)
74 (9.9)
Total Number of Grade 3 or 4  ALT, AST, or Bilirubin
0 (0%) 
17 (22.7%)
Discontinued treatment
10 (1.3%)
With Grade 4
7 (0.9%)
With Grade 3
3 (0.4%)
10 (1.3%)
Interrupted
23 (3.1%)
47 (6.3%)
No interruption
26 (3.5%)
57 (7.6%)
Continued treatment