Partial List of Known Oncogenic Viruses*

(Tumor formation in the species listed)

Virus

Syrian

Hamsters

Mice

Rats

Other

Reference

Oncogenic retroviruses:

helper-independ.

Examples: (1-2 below)

 

1. Rous sarcoma  virus

+

 

   Swiss

 

Sprague-Dawley

 

guinea pig; cotton rats; Chinese hamsters; rhesus monkeys; marmosets; rabbits; dogs

Rous, 1911

Ahlstrom, 1962

Munroe, 1964,

Svet-Moldavskia., 1964,

Harris, 1964  1

 

 

2. HTLV 1 -2

?

?

?

humans

Reoitz 1981 2 

Oncogenic retroviruses

helper -dependent

  Examples:  (1 - 9

   below)

 

?

?

?

avians, felines, bovines,  ovines, non-human primates

Coffin, Hughes, Varmus, 1997 3 

 1. Murine sarcoma

      viruses

     (Harvey)

+

BALB/c

Chester Betty hooded

mastomys

Harvey 1964, 1968  4

2. Murine sarcoma

    (Moloney)

Not oncogenic

BALB/c

Not oncogenic

none

Moloney, 1966 5

3. Murine sarcoma

      (Kirsten)

 ?

C3H(f) 

WistarFurth

 

?

Kirsten,  1967 6

4. Mouse

       leukemia virus

   (Gross)

not oncogenic

C3H

Sprague-Dawley, Osborne-Mendal      

none reported

 

Gross, 1951, 1970,

Graffi, 1960 7

 

5.  Mouse

      leukemia virus

     (Graffi)

?

AB

Wistar (10%)

?

Graffi, 1957, 1959 8

6. Murine

    leukemia virus

   (Moloney)

?

BALB/c

?

?

Moloney 1960  9

7. Murine

    leukemia virus

    (Friend)

                ?

Swiss

Sprague-Dawley

         ?

Friend 1957,

Mirand 1962  10

8. Murine

     leukemia virus

    (Raucher)

                ?

BALB/c

Osborne-Mendal

        ?

Rauscher 1962,11

9. Hamster

    leukemia

+

?

?

?

Kelloff , 1970  12

Polyomavirus

Outbred

C3H

Sprague-Dawley

guinea pig, ferret,

mastomy

Gross, 1953

Stewart, 1955,

Eddy, 1958, 1959,

Harris, 1961,

Rabson ,  1960  13

SV40

+

CFW

             0

mastomys

Eddy, 1964,

Wesslen 1970,

Harris, 1979,

Abzamczuk 1984

Rabson 1962  14

JCV

               +

             0

            0

 

Walker 1973  15

BK

               +

             0

            0

 

Shah 1975

Klein 1980  16

Ad12,18, 21, 31

               +

             +

           +

 

Huebner, 1967,

Gross, 1970  17

Ad3,7,14,16,21

               +

             ?

             ?

 

Huebner 1967  18

Ad9

               0

             0

             +

 

Javier 1991 19

SA7 (AGMK)

               +

            +

             +

 

Hull,  1965  20

CELO (chicken)

               +

            0

             0

 

Sarma, 1965  21

Canine hepatitis virus (Ad)

               +

            ?

            ?

 

Sarma,  1967, 22

Bovine papilloma virus

               +

             +

            ?

 

Freidman, 1963,

Gross, 1970  23

Epstein Barr virus

               0

             0

            0

rabbits

Tooze 1973,

Koirala 1997 24

Cytomegalovirus

               0

            + (cervical           neoplasia)

            0  

 

Aaronson ,1974

Heggie, 1986,

Similey 1988,

Shen, 1997 25

Herpes simplex 1

               0

            0

            0

 

Tooze 1973  26

Herpes simplex 2

              +

            +

            0

 

ibid 27

Hepes saimiri

              0

            0

            0

 

ibid 27

Herpes atles

              0

            0

            0

 

ibid 29

Marak’s disease

              0

            0

            0

 

ibid 30

HHS 8

              ?

            ?

            ?

humans

Chang 1994  31

 Hamster polyomavirus Infectlymphoma synd

              +

            ?

            ?

 

Coggins 1981,

Leinbach, 1987 32

*Prepared by Andrew Lewis, Keith Peden, Arifa Khan, and Philip  Krause, DVP, OVRR, CBER

 References:

1. Rous J Exp Med 13: 397, 1911; Ahlstrom et al.  J Exp Med 115: 839-852, 1962; Ahlstrom et al.  Acta Path Micro Scan (Suppl) 154:127-129, 1962;  Ahlstrom,  NCI Monograph 17, p299-319, 1964;   Munroe et al. JNCI, 32:591, 1964;   Munroe et al.  NCI Monograph 17, p365-390, 1964; Svet-Moldavskaja, Science 143: 54-55,1964; Harris et al.   NCI Monograph 17, p321-335, 1964;

 2. Reitz et al. ,  PNAS 78: 1887, 1981;

3. Retroviruses, Coffin, Hughes, Varmus eds, Cold Spring Harbor Press, 1997

4. Harvey, Nature 204:1104-1105, 1964; ibid Int J. Ca, 3: 634-643,1968

5. Moloney NCI Mongraph 22: 139-142, 1966;

6. Kirsten et al. JNCI: 38: 117-139, 1967

7. Gross,  Proc Exp Biol Med 76:27-32, 1951; ibid Oncogenic Viruses , p286-469, 1970; Graffi, Prog Exp Tumor Res p112-161, 1960

8. Graffi, Ann NY Acad Sci 68: 540-558, 1957   Graffi et al Zeitschr f Naturforsch 14b: 747-748, 1959

9. Moloney, JNCI, 24:933-951, 1960

10. Friend ,  J Exp Med: 307-318, 1957;  Mirand et al. Virology 17: 364-366, 1962

11. Raucher, JNCI 29:515-543, 1962

12. Kelloff et al.  Proc Nat Acad Sci 65:310-317, 1970;

13. Gross, Proc Soc Exptl Biol Med, 83: 4140421, 1953; Stewart JNCI 15: 1391-1415, 1955; Eddy, JNCI,

       20;747-761, 1958; Eddy, JNCI, 22;161-171, 1959; Eddy , Adv Virus Res 7:91-102, 1960;   Harris et al.,

       Lancet 1: 788-791, 1961; Rabson et al.  Nature 187: 423-425, 1960

14. Eddy, Prog Exp Tumor Res 4;1-26, 1964, Wesslen, Acta Path Microbiol Scand; 78; 479-487, 1970;

      Abramczuk J Virol 49; 540-548, 1984; Hargis et al. JNCI, 63:965-968, 1979; Rabson et al. ,JNCI 29:765-

      787, 1962;

15. Walker, Science, 181; 674-676, 1973

16. Shah, JNCI, 54;945-950, 1975

       Klein,Viral Oncology p506-526, 1980

17. Huebner, Perspectives in Virology V, p147-166, 1967  Gross, Oncogenic Viruses , p784-815, 1970

18. Huebner, Perspectives in Virology V, p147-166, 1967

19. Javier , J Virol, 65;3192-202, 1991

20. Hull, Science 150;1044-1046, 1965

21. Sarma, Science, 149;1108, 1965

22. Sarma, Nature, 215; 293-294, 1967

23. Freidmann, Compt Rendu Acad Sci, 257; 2328-2331, 1963;

Gross, Oncogenic Viruses , p65-81, 1970

24. Tooze, Mol Biol Tumor Viruses, p487-490, 1973;

Koirala et al.  Pathol Int 47: 442, 1997

25. Aaronson, Science ,183; 422-424,  1974; Heggie et al Can Res, 46; 5211-5214, 1986; Smiley et al J Med Virol; 25;213-226, 1988; Shen et al PNAS, 94; 3341-3345, 1997

26 - 30. Tooze, Mol Biol Tumor Viruses, p487-490, 1973

31.  Chang et al. Science 266: 1856, 1994

32. Coggins,  Nature 290; 336-338, 1981; Leinbach et al. J NCI 79:273, 1987