CE-14
Exercise
Duration by Subgroup—
Borderline Vital Signs or AV Conduction†
MARISA (CVT 3031) and CARISA (CVT 3033)
Borderline Vital Signs or AV Conduction†
MARISA (CVT 3031) and CARISA (CVT 3033)
500
1000
1500
500
1000
1500
750
1000
750
1000
Ranolazine
treatment,
mg bid
treatment,
mg bid
n = 29
n = 29
n = 28
n = 29
n = 29
n = 29
n = 88
n = 81
n = 88
n = 82
Difference from placebo, sec
Difference from placebo, sec
n = 145
n = 145
n = 139
n = 145
n = 145
n = 140
n = 182
n = 174
n = 184
n = 179
Borderline VS or
AV conduction
(interaction test
p-value)
AV conduction
(interaction test
p-value)
In subgroup
Not in subgroup
MARISA peak
p = 0.74
MARISA trough
p = 0.54
CARISA peak
p = 0.51
CARISA trough
p = 0.75
†SBP ≤ 100 mm Hg, HR ≤ 60 bpm, or PR interval
≥ 200 msec.