CE-12
Ranolazine Concentration Predicts Response
Across the Chronic Angina Population—
Population-Based Analysis of Exercise Duration
§Four double-blind, placebo-controlled studies
–MARISA, CARISA and 2 IR studies
–1397 patients (1073 men, 324 women)
–10,998 ETT-plasma concentration pairs
§No influence on concentration-response
–Demographic factors: age, weight, and race
–Concurrent diseases: CHF class, diabetes
–Background anti-anginal therapy
§Men and women respond differently
–Women: 6.4 sec/1000 ng/mL, 95% CI (3.1, 9.7)
–Men: 16.8 sec/1000 ng/mL, 95% CI (14.6, 19.0)