§Demonstrated
in 5 double-blind, randomized, placebo-controlled studies
§Dose and plasma
concentration dependent
§Observed in a broad
population with severe
coronary disease
§Not dependent upon
decreases in blood pressure or heart rate
§At least as great as
atenolol 100 mg qd
§In patients on
atenolol or diltiazem at doses considered optimal by their
physicians