-----Original Message-----
From: Terry S. Singeltary
Sr. [mailto:flounder@wt.net]
Sent: Tuesday, February 18,
2003 12:45 PM
To: Freas, William
Cc: Langford, Sheila
Subject: Re: re-vCJD/blood
and meeting of Feb. 20, 2003
Greetings FDA,
Variant Creutzfeldt-Jakob
Disease Guidance Topic of Feb. 20 TSE Cmte.
[Committee Meeting on
February 20, 2003]
FDA’s Transmissible
Spongiform Encephalopathies Advisory Committee will
meet Feb. 20 to hear updates
on the implementation of the agency’s
variant Creutzfeldt-Jakob
Disease guidance and its effect on blood
supply. FULL STORY>>
my name is Terry S.
Singeltary Sr., and i lost my mother
to hvCJD, one of six known
phenotypes of sporadic CJD.
i would like to observe this
meeting or participate,
but have no financial means
to do so with. i am disabled
from neck injury. anyway, i
am not sure if a waiver of
fees is possible? i belong
to several groups trying to
track the true extent of
CJDs and trying to find the truth.
with CJDs not being
reportable but only in a handful of
states, and the fact there
is no CJD Questionnaire being
issued to victims and their
families that asks any questions
pertaining to route and
source, i think to track tainted
blood will be futile. i had
a major neck surgery in 2001 (3rd),
and not _one_ question
pertaining to CJD/TSE on any paperwork
(and damn near died from
MRSA after refusing blood and
cadaver bone for fear of
risk of CJD/TSEs, go figure,
7 weeks vancomycin via PIC
long-line straight to heart).
luckily i had informed my
neurosurgeon and he did use some
disposable instruments and a
bone grinder that would not
be used again. i would like
to submit my concerns on the
vCJD _only_ theory as being
a total mistake, and that no one
knows just how many strains
are actually linked to tainted meat
and the oral route (one of
many potential routes). Asante/Collinge
et al have major findings on
sporadic CJD, why in the hell is
this not making big news in
the USA? ($$$)
the fact that with the new
findings from Collinge et al,
that BSE transmission to the
129-methionine genotype can lead
to an alternate phenotype
which is indistinguishable from
type 2 PrPSc, the commonest
sporadic CJD, i only ponder how
many of the sporadic CJDs in
the USA are tied to this alternate
phenotype? these new
findings are very serious, and should have
a major impact on the way
sporadic CJDs are now treated as opposed
to the vCJD that was thought
to be the only TSE tied to ingesting
beef, in the
medical/surgical arena. these new findings should have
a major impact on the way sporadic
CJD is ignored, and should now be
moved to the forefront of
research as with vCJD/nvCJD. the USA has
many TSEs, the USA lacks
sufficient testing for TSEs in cattle, and
the USA still refuses to
rapid TSE test USA cattle in sufficient
numbers to find, when the
late Dr. Richard Marsh had proven
that mink had gone down with
a TSE (TME), from being fed
on 95%+ downer cattle. the
GAO has also warned the industry
and the FDA that the
ruminant-to-ruminant feed ban has to
significantly improved if
they expect to keep BSE/TSEs out
of USA cattle. Scrapie has
increased significantly, and
CWD is spreading. with the
titre of infectivity for lethal
dose getting smaller (.1
gram lethal), seems the risk of
transmission through various
potential routes and sources
are rising. all this should
warrant CJD/TSEs in humans in
the USA to be made
reportable on a National bases immediately,
and a CJD questionnaire to
all CJD/TSE victims and their families.
to flounder on these two
very important issues, will only allow
the agent to spread
further...
-------- Original Message
-------- Subject: re-BSE prions propagate as
either variant CJD-like or
sporadic CJD Date: Thu, 28 Nov 2002 10:23:43
-0000 From: "Asante,
Emmanuel A" <e.asante@ic.ac.uk> To: "'flounder@wt.net'"
<flounder@wt.net>
Dear Terry,
I have been asked by
Professor Collinge to respond to your request. I am
a Senior Scientist in the
MRC Prion Unit and the lead author on the
paper. I have attached a pdf
copy of the paper for your attention. Thank
you for your interest in the
paper.
In respect of your first
question, the simple answer is, yes. As you
will find in the paper, we
have managed to associate the alternate
phenotype to type 2 PrPSc,
the commonest sporadic CJD.
It is too early to be able
to claim any further sub-classification in
respect of Heidenhain
variant CJD or Vicky Rimmer's version. It will
take further studies, which
are on-going, to establish if there are
sub-types to our initial
finding which we are now reporting. The main
point of the paper is that,
as well as leading to the expected new
variant CJD phenotype, BSE
transmission to the 129-methionine genotype
can lead to an alternate
phenotype which is indistinguishable from type
2 PrPSc.
I hope reading the paper
will enlighten you more on the subject. If I
can be of any further
assistance please to not hesitate to ask. Best wishes.
Emmanuel Asante
<<Asante et al
2002.pdf>> ____________________________________
Dr. Emmanuel A Asante MRC
Prion Unit & Neurogenetics Dept. Imperial
College School of Medicine
(St. Mary's) Norfolk Place, LONDON W2 1PG
Tel: +44 (0)20 7594 3794
Fax: +44 (0)20 7706 3272 email:
e.asante@ic.ac.uk (until
9/12/02)
New e-mail:
e.asante@prion.ucl.ac.uk (active from now)
____________________________________
i have posted full text copy
of the above data here;
PLEASE SEE FULL TEXT OF THIS
ARTICLE;
http://www.vegsource.com/talk/madcow/messages/9912118.html
Diagnosis and Reporting of
Creutzfeldt-Jakob Disease T. S. Singeltary,
Sr; D. E. Kraemer; R. V.
Gibbons, R. C. Holman, E. D. Belay, L. B.
Schonberger
http://jama.ama-assn.org/issues/v285n6/ffull/jlt0214-2.html
# Re: BSE .1 GRAM LETHAL NEW
STUDY SAYS via W.H.O. Dr Maura Ricketts
[BBC radio 4 FARM news]
http://www.vegsource.com/talk/madcow/messages/9912425.html
#Docket No. 01-068-1 Risk
Reduction Strategies for Potential BSE
Pathways Involving Downer
Cattle and Dead Stock of Cattle and Other
Species - TSS 1/21/03 (2)
http://www.vegsource.com/talk/madcow/messages/9912348.html
In Reply to: Docket No.
01-068-1 Risk Reduction Strategies for Potential
BSE Pathways Involving
Downer Cattle and Dead Stock of Cattle and Other
Species [TSS SUBMISSION]
January 21, 2003
http://www.vegsource.com/talk/madcow/messages/9912358.html
Re: Docket No. 01-068-1 --
(200,000 USA DOWNERS ANNUALLY) TSS 1/21/03
http://www.vegsource.com/talk/madcow/messages/9912360.html
Re: Docket No. 02N-0273 -
Substances Prohibited From Use In Animal Food
Or Feed;
http://www.vegsource.com/talk/madcow/messages/9912338.html
# Re: [Docket No. 99-017-2]
Blood and Tissue Collection at Slaughtering
Establishments [TSS
SUBMISSION]
http://www.vegsource.com/talk/madcow/messages/9912402.html
# Docket No: 02-088-1
RE-Agricultural Bioterrorism Protection Act of
2002; [TSS SUBMISSION ON
POTENTIAL FOR BSE/TSE & FMD 'SUITCASE BOMBS'] -
TSS 1/27/03 (0)
http://www.vegsource.com/talk/madcow/messages/9912395.html
STUDY DESIGN AND METHODS:
BSE was passaged through macaque monkeys and
then adapted to the
prosimian microcebe (Microcebus murinus ). Brain
homogenate and buffy coat
from an affected microcebe were separately
inoculated intracerebrally
into three healthy microcebes (two animals
received brain and one
received buffy coat).
RESULTS: All three
inoculated microcebes became ill after incubation
periods of 16 to 18 months.
Clinical, histopathologic, and
immunocytologic features
were similar in each of the recipients.
CONCLUSION: Buffy coat from
a symptomatic microcebe infected 17 months
earlier with BSE contained
the infectious agent. This observation
represents the first
documented transmission of BSE from the blood of an
experimentally infected
primate, which in view of rodent buffy coat
infectivity precedents and
the known host range of BSE is neither
unexpected nor cause for
alarm.
http://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showAbstract&doi=10.1046/j.1537-2995.2002.00098.x
Transmission of prion
diseases by blood transfusion
Nora Hunter,1 James Foster,1
Angela Chong,1 Sandra McCutcheon,2 David
Parnham,1 Samantha Eaton,1 Calum
MacKenzie1 and Fiona Houston2
see full text;
http://www.socgenmicrobiol.org.uk/JGVDirect/18580/18580ft.pdf
1: J Neurol Neurosurg
Psychiatry 1994 Jun;57(6):757-8 Related Articles,
Help Links
Transmission of Creutzfeldt-Jakob disease to a chimpanzee by
electrodes contaminated
during neurosurgery.
Gibbs CJ Jr, Asher DM, Kobrine A, Amyx HL, Sulima MP, Gajdusek
DC.
Laboratory of Central Nervous System Studies, National
Institute of
Neurological Disorders and
Stroke, National Institutes of Health,
Bethesda, MD 20892.
Stereotactic multicontact electrodes used to probe the
cerebral
cortex of a middle aged
woman with progressive dementia were previously
implicated in the accidental
transmission of Creutzfeldt-Jakob disease
(CJD) to two younger
patients. The diagnoses of CJD have been confirmed
for all three cases. More
than two years after their last use in humans,
after three cleanings and
repeated sterilisation in ethanol and
formaldehyde vapour, the
electrodes were implanted in the cortex of a
chimpanzee. Eighteen months
later the animal became ill with CJD. This
finding serves to
re-emphasise the potential danger posed by reuse of
instruments contaminated
with the agents of spongiform encephalopathies,
even after scrupulous
attempts to clean them.
PMID: 8006664
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8006664&dopt=Abstract
we have taken this agent too
lightly for decades in the USA.
we must act now, and we must
act with all human/animal TSEs...
TSS
Terry S. Singeltary Sr.
P.O. Box 42 Bacliff,
Texas USA 77518
<flounder@wt.net>
CJD WATCH
http://www.fortunecity.com/healthclub/cpr/349/part1cjd.htm
CJD Watch/NEWS message board
http://disc.server.com/Indices/167318.html
TSS