-----Original Message-----

From: Terry S. Singeltary Sr. [mailto:flounder@wt.net]

Sent: Tuesday, February 18, 2003 12:45 PM

To: Freas, William

Cc: Langford, Sheila

Subject: Re: re-vCJD/blood and meeting of Feb. 20, 2003

 

 

Greetings FDA,

 

 

Variant Creutzfeldt-Jakob Disease Guidance Topic of Feb. 20 TSE Cmte.

[Committee Meeting on February 20, 2003]

FDAs Transmissible Spongiform Encephalopathies Advisory Committee will

meet Feb. 20 to hear updates on the implementation of the agencys

variant Creutzfeldt-Jakob Disease guidance and its effect on blood

supply. FULL STORY>>

 

my name is Terry S. Singeltary Sr., and i lost my mother

to hvCJD, one of six known phenotypes of sporadic CJD.

i would like to observe this meeting or participate,

but have no financial means to do so with. i am disabled

from neck injury. anyway, i am not sure if a waiver of

fees is possible? i belong to several groups trying to

track the true extent of CJDs and trying to find the truth.

with CJDs not being reportable but only in a handful of

states, and the fact there is no CJD Questionnaire being

issued to victims and their families that asks any questions

pertaining to route and source, i think to track tainted

blood will be futile. i had a major neck surgery in 2001 (3rd),

and not _one_ question pertaining to CJD/TSE on any paperwork

(and damn near died from MRSA after refusing blood and

cadaver bone for fear of risk of CJD/TSEs, go figure,

7 weeks vancomycin via PIC long-line straight to heart).

luckily i had informed my neurosurgeon and he did use some

disposable instruments and a bone grinder that would not

be used again. i would like to submit my concerns on the

vCJD _only_ theory as being a total mistake, and that no one

knows just how many strains are actually linked to tainted meat

and the oral route (one of many potential routes). Asante/Collinge

et al have major findings on sporadic CJD, why in the hell is

this not making big news in the USA? ($$$)

the fact that with the new findings from Collinge et al,

that BSE transmission to the 129-methionine genotype can lead

to an alternate phenotype which is indistinguishable from

type 2 PrPSc, the commonest sporadic CJD, i only ponder how

many of the sporadic CJDs in the USA are tied to this alternate

phenotype? these new findings are very serious, and should have

a major impact on the way sporadic CJDs are now treated as opposed

to the vCJD that was thought to be the only TSE tied to ingesting

beef, in the medical/surgical arena. these new findings should have

a major impact on the way sporadic CJD is ignored, and should now be

moved to the forefront of research as with vCJD/nvCJD. the USA has

many TSEs, the USA lacks sufficient testing for TSEs in cattle, and

the USA still refuses to rapid TSE test USA cattle in sufficient

numbers to find, when the late Dr. Richard Marsh had proven

that mink had gone down with a TSE (TME), from being fed

on 95%+ downer cattle. the GAO has also warned the industry

and the FDA that the ruminant-to-ruminant feed ban has to

significantly improved if they expect to keep BSE/TSEs out

of USA cattle. Scrapie has increased significantly, and

CWD is spreading. with the titre of infectivity for lethal

dose getting smaller (.1 gram lethal), seems the risk of

transmission through various potential routes and sources

are rising. all this should warrant CJD/TSEs in humans in

the USA to be made reportable on a National bases immediately,

and a CJD questionnaire to all CJD/TSE victims and their families.

to flounder on these two very important issues, will only allow

the agent to spread further...

 

-------- Original Message -------- Subject: re-BSE prions propagate as

either variant CJD-like or sporadic CJD Date: Thu, 28 Nov 2002 10:23:43

-0000 From: "Asante, Emmanuel A" <e.asante@ic.ac.uk> To: "'flounder@wt.net'"

<flounder@wt.net>

 

Dear Terry,

 

I have been asked by Professor Collinge to respond to your request. I am

a Senior Scientist in the MRC Prion Unit and the lead author on the

paper. I have attached a pdf copy of the paper for your attention. Thank

you for your interest in the paper.

 

In respect of your first question, the simple answer is, yes. As you

will find in the paper, we have managed to associate the alternate

phenotype to type 2 PrPSc, the commonest sporadic CJD.

It is too early to be able to claim any further sub-classification in

respect of Heidenhain variant CJD or Vicky Rimmer's version. It will

take further studies, which are on-going, to establish if there are

sub-types to our initial finding which we are now reporting. The main

point of the paper is that, as well as leading to the expected new

variant CJD phenotype, BSE transmission to the 129-methionine genotype

can lead to an alternate phenotype which is indistinguishable from type

2 PrPSc.

 

I hope reading the paper will enlighten you more on the subject. If I

can be of any further assistance please to not hesitate to ask. Best wishes.

 

Emmanuel Asante

<<Asante et al 2002.pdf>> ____________________________________

Dr. Emmanuel A Asante MRC Prion Unit & Neurogenetics Dept. Imperial

College School of Medicine (St. Mary's) Norfolk Place, LONDON W2 1PG

Tel: +44 (0)20 7594 3794 Fax: +44 (0)20 7706 3272 email:

e.asante@ic.ac.uk (until 9/12/02)

New e-mail: e.asante@prion.ucl.ac.uk (active from now)

____________________________________

 

i have posted full text copy of the above data here;

 

PLEASE SEE FULL TEXT OF THIS ARTICLE;

 

http://www.vegsource.com/talk/madcow/messages/9912118.html

 

Diagnosis and Reporting of Creutzfeldt-Jakob Disease T. S. Singeltary,

Sr; D. E. Kraemer; R. V. Gibbons, R. C. Holman, E. D. Belay, L. B.

 

Schonberger http://jama.ama-assn.org/issues/v285n6/ffull/jlt0214-2.html

 

# Re: BSE .1 GRAM LETHAL NEW STUDY SAYS via W.H.O. Dr Maura Ricketts

[BBC radio 4 FARM news]

 

http://www.vegsource.com/talk/madcow/messages/9912425.html

 

#Docket No. 01-068-1 Risk Reduction Strategies for Potential BSE

Pathways Involving Downer Cattle and Dead Stock of Cattle and Other

Species - TSS 1/21/03 (2)

 

http://www.vegsource.com/talk/madcow/messages/9912348.html

 

In Reply to: Docket No. 01-068-1 Risk Reduction Strategies for Potential

BSE Pathways Involving Downer Cattle and Dead Stock of Cattle and Other

Species [TSS SUBMISSION] January 21, 2003

 

http://www.vegsource.com/talk/madcow/messages/9912358.html

 

Re: Docket No. 01-068-1 -- (200,000 USA DOWNERS ANNUALLY) TSS 1/21/03

 

http://www.vegsource.com/talk/madcow/messages/9912360.html

 

Re: Docket No. 02N-0273 - Substances Prohibited From Use In Animal Food

Or Feed;

 

http://www.vegsource.com/talk/madcow/messages/9912338.html

 

# Re: [Docket No. 99-017-2] Blood and Tissue Collection at Slaughtering

Establishments [TSS SUBMISSION]

 

http://www.vegsource.com/talk/madcow/messages/9912402.html

 

# Docket No: 02-088-1 RE-Agricultural Bioterrorism Protection Act of

2002; [TSS SUBMISSION ON POTENTIAL FOR BSE/TSE & FMD 'SUITCASE BOMBS'] -

TSS 1/27/03 (0)

 

http://www.vegsource.com/talk/madcow/messages/9912395.html

 

STUDY DESIGN AND METHODS: BSE was passaged through macaque monkeys and

then adapted to the prosimian microcebe (Microcebus murinus ). Brain

homogenate and buffy coat from an affected microcebe were separately

inoculated intracerebrally into three healthy microcebes (two animals

received brain and one received buffy coat).

 

RESULTS: All three inoculated microcebes became ill after incubation

periods of 16 to 18 months. Clinical, histopathologic, and

immunocytologic features were similar in each of the recipients.

 

CONCLUSION: Buffy coat from a symptomatic microcebe infected 17 months

earlier with BSE contained the infectious agent. This observation

represents the first documented transmission of BSE from the blood of an

experimentally infected primate, which in view of rodent buffy coat

infectivity precedents and the known host range of BSE is neither

unexpected nor cause for alarm.

 

http://www.blackwell-synergy.com/servlet/useragent?func=synergy&synergyAction=showAbstract&doi=10.1046/j.1537-2995.2002.00098.x

 

Transmission of prion diseases by blood transfusion

 

Nora Hunter,1 James Foster,1 Angela Chong,1 Sandra McCutcheon,2 David

Parnham,1 Samantha Eaton,1 Calum MacKenzie1 and Fiona Houston2

 

see full text;

 

http://www.socgenmicrobiol.org.uk/JGVDirect/18580/18580ft.pdf

 

1: J Neurol Neurosurg Psychiatry 1994 Jun;57(6):757-8 Related Articles,

Help Links

 

Transmission of Creutzfeldt-Jakob disease to a chimpanzee by

electrodes contaminated during neurosurgery.

 

Gibbs CJ Jr, Asher DM, Kobrine A, Amyx HL, Sulima MP, Gajdusek DC.

 

Laboratory of Central Nervous System Studies, National Institute of

Neurological Disorders and Stroke, National Institutes of Health,

Bethesda, MD 20892.

 

Stereotactic multicontact electrodes used to probe the cerebral

cortex of a middle aged woman with progressive dementia were previously

implicated in the accidental transmission of Creutzfeldt-Jakob disease

(CJD) to two younger patients. The diagnoses of CJD have been confirmed

for all three cases. More than two years after their last use in humans,

after three cleanings and repeated sterilisation in ethanol and

formaldehyde vapour, the electrodes were implanted in the cortex of a

chimpanzee. Eighteen months later the animal became ill with CJD. This

finding serves to re-emphasise the potential danger posed by reuse of

instruments contaminated with the agents of spongiform encephalopathies,

even after scrupulous attempts to clean them.

 

PMID: 8006664

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8006664&dopt=Abstract

 

we have taken this agent too lightly for decades in the USA.

we must act now, and we must act with all human/animal TSEs...

 

TSS

 

Terry S. Singeltary Sr.

P.O. Box 42 Bacliff,

Texas USA 77518

<flounder@wt.net>

 

CJD WATCH

 

http://www.fortunecity.com/healthclub/cpr/349/part1cjd.htm

 

CJD Watch/NEWS message board

 

http://disc.server.com/Indices/167318.html

 

TSS