Table of Contents
Hepatitis B
Hepatitis B
Hepatitis B Virus
PPT Slide
PPT Slide
Hepatitis B Viral Genome
Infectious cycle of hepatitis B virus
Hepatitis B Virus Mutants
Hepatitis B Core Antigen Mutants
HBeAg-negative Variants
PPT Slide
Typical Acute Hepatitis B
Typical Chronic Hepatitis B
Chronic Hepatitis B: Transition to Inactive Carrier State
Evolution of HBeAg Negative Mutant
Chronic Hepatitis B: Three Clinical Forms:
Chronic Hepatitis B: Clinical Forms: HBV DNA levels
PPT Slide
Genotypes of Hepatitis B Virus
Acute Hepatitis B Sentinel County Study: 1982-98
PPT Slide
Chronic Liver Disease: United States 1999
Chronic Hepatitis B Long-Term Complications
Chronic Hepatitis B Histology
Chronic Hepatitis B Histology Scoring Systems
Chronic Hepatitis B Histology Scoring Systems
Therapy of Hepatitis B
Chronic Hepatitis B Goals of Therapy
Therapy of Chronic Hepatitis B: Major Issues
Definition of Responses to Therapy in Chronic Hepatitis B
Virological Response in Chronic Hepatitis B
Virological Response in Chronic Hepatitis B
Virological Response in Chronic Hepatitis B
Biochemical Response in Chronic Hepatitis B
Histological Response in Chronic Hepatitis B
Alpha Interferon
Chronic Hepatitis B Long-term Response to Interferon
Chronic Hepatitis B Response to Interferon & Relapse
HBeAg-Negative Chronic Hepatitis B Response to Interferon and Relapse
Interferon for Chronic Hepatitis B: Problems
Lamivudine
Lamivudine Therapy Maintained Response
HBeAg-Negative Chronic Hepatitis B
Lamivudine Therapy: Viral Resistance
Lamivudine for Chronic Hepatitis B Histology Activity Index Scores
PPT Slide
Lamivudine Therapy Late Relapse
PPT Slide
Lamivudine
Optimal Therapy of Hepatitis B?
Management of Hepatitis B
Therapy of Chronic Hepatitis B: Future Directions
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