Hepatitis B

8/14/02


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Table of Contents

Hepatitis B

Hepatitis B

Hepatitis B Virus

PPT Slide

PPT Slide

Hepatitis B Viral Genome

Infectious cycle of hepatitis B virus

Hepatitis B Virus Mutants

Hepatitis B Core Antigen Mutants

HBeAg-negative Variants

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Typical Acute Hepatitis B

Typical Chronic Hepatitis B

Chronic Hepatitis B: Transition to Inactive Carrier State

Evolution of HBeAg Negative Mutant

Chronic Hepatitis B: Three Clinical Forms:

Chronic Hepatitis B: Clinical Forms: HBV DNA levels

PPT Slide

Genotypes of Hepatitis B Virus

Acute Hepatitis B Sentinel County Study: 1982-98

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Chronic Liver Disease: United States 1999

Chronic Hepatitis B Long-Term Complications

Chronic Hepatitis B Histology

Chronic Hepatitis B Histology Scoring Systems

Chronic Hepatitis B Histology Scoring Systems

Therapy of Hepatitis B

Chronic Hepatitis B Goals of Therapy

Therapy of Chronic Hepatitis B: Major Issues

Definition of Responses to Therapy in Chronic Hepatitis B

Virological Response in Chronic Hepatitis B

Virological Response in Chronic Hepatitis B

Virological Response in Chronic Hepatitis B

Biochemical Response in Chronic Hepatitis B

Histological Response in Chronic Hepatitis B

Alpha Interferon

Chronic Hepatitis B Long-term Response to Interferon

Chronic Hepatitis B Response to Interferon & Relapse

HBeAg-Negative Chronic Hepatitis B Response to Interferon and Relapse

Interferon for Chronic Hepatitis B: Problems

Lamivudine

Lamivudine Therapy Maintained Response

HBeAg-Negative Chronic Hepatitis B

Lamivudine Therapy: Viral Resistance

Lamivudine for Chronic Hepatitis B Histology Activity Index Scores

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Lamivudine Therapy Late Relapse

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Lamivudine

Optimal Therapy of Hepatitis B?

Management of Hepatitis B

Therapy of Chronic Hepatitis B: Future Directions

Author: Dr. Jay Hoofnagle