Study 435 Pre-Transplantation Patients with Confirmed Increases in Serum Creatinine ? 0.5 mg/dL from Baseline (n=15)

• Serum creatinine increase post liver transplantation (n=11)

• Decompensated cirrhosis (n=3)

  • Disease progression or addition of gentamicin

• Non-treatment emergent (n=1)

  • 3 months following last dose of ADV

Through NDA Safety Update

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