Lamivudine Resistance

• Incidence of mutations (YMDD)1-3

  • 24% at 1 year
  • 69% at 5 years

• Resistance associated with

  • Loss of HBV DNA suppression
  • Increased ALT
  • Loss of histological and clinical benefit

1 Lai et al. Gastroenterol Hepatol, 2000

2 Leung MWY et al. J Hepatology, 1999

3 Guan et al. APDW, 2002

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