Studies 437 and 438Resistance Surveillance

• Prospective, blinded analysis

• Methods

  • Sequenced RT domain of HBV DNA polymerase (344 amino acids)
  • Compared baseline and week 48
  • Assessed phenotypic resistance in vitro for all emerging substitutions at conserved sites

• 498 of 695 patients with paired samples had detectable HBV DNA > 400 copies/mL at baseline and week 48

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